Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis and may be an upstream contributor to cognitive d...

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Autores principales:	Daniel Felsky, Tina Roostaei, Kwangsik Nho, Shannon L. Risacher, Elizabeth M. Bradshaw, Vlad Petyuk, Julie A. Schneider, Andrew Saykin, David A. Bennett, Philip L. De Jager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c2b0cd3de2c44ac9e972835b9851021
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spelling	oai:doaj.org-article:5c2b0cd3de2c44ac9e972835b98510212021-12-02T17:33:11ZNeuropathological correlates and genetic architecture of microglial activation in elderly human brain10.1038/s41467-018-08279-32041-1723https://doaj.org/article/5c2b0cd3de2c44ac9e972835b98510212019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08279-3https://doaj.org/toc/2041-1723The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis and may be an upstream contributor to cognitive decline via the accumulation of tau pathology.Daniel FelskyTina RoostaeiKwangsik NhoShannon L. RisacherElizabeth M. BradshawVlad PetyukJulie A. SchneiderAndrew SaykinDavid A. BennettPhilip L. De JagerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Felsky Tina Roostaei Kwangsik Nho Shannon L. Risacher Elizabeth M. Bradshaw Vlad Petyuk Julie A. Schneider Andrew Saykin David A. Bennett Philip L. De Jager Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
description	The consequences of microglial activation in the aging human brain remain unknown. This study quantified microglial morphology and density in the elderly human brain to show that cortical microglial activation strongly associates with AD pathogenesis and may be an upstream contributor to cognitive decline via the accumulation of tau pathology.
format	article
author	Daniel Felsky Tina Roostaei Kwangsik Nho Shannon L. Risacher Elizabeth M. Bradshaw Vlad Petyuk Julie A. Schneider Andrew Saykin David A. Bennett Philip L. De Jager
author_facet	Daniel Felsky Tina Roostaei Kwangsik Nho Shannon L. Risacher Elizabeth M. Bradshaw Vlad Petyuk Julie A. Schneider Andrew Saykin David A. Bennett Philip L. De Jager
author_sort	Daniel Felsky
title	Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
title_short	Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
title_full	Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
title_fullStr	Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
title_full_unstemmed	Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
title_sort	neuropathological correlates and genetic architecture of microglial activation in elderly human brain
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5c2b0cd3de2c44ac9e972835b9851021
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Neuropathological correlates and genetic architecture of microglial activation in elderly human brain

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