Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients

Abstract Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control...

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Autores principales:	Takayuki Kawai, Ryuji Sakakibara, Yosuke Aiba, Fuyuki Tateno, Tsuyoshi Ogata, Setsu Sawai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c2c0f9ef6d74f1aa5c5f325ae63a07c
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spelling	oai:doaj.org-article:5c2c0f9ef6d74f1aa5c5f325ae63a07c2021-12-02T18:49:28ZIncreased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients10.1038/s41598-021-95343-62045-2322https://doaj.org/article/5c2c0f9ef6d74f1aa5c5f325ae63a07c2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95343-6https://doaj.org/toc/2045-2322Abstract Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects (12 men, 12 women; mean age 38.2 years [17–65 years]; age did not correlate with csfBAP in this group). We performed brain MRI in all TGA patients, and CA1 lesions were noted by MRI in 5 subjects. We measured csfBAP, total antioxidant properties, in all TGA patients and controls. csfBAP levels were higher in TGA patients than in controls (p = 0.024, 0.028). csfBAP levels in TGA patients did not differ between MRI-positive and -negative subgroups. Elevated csfBAP levels were observed in TGA patients, suggesting that oxidative stress may have a role in the pathogenesis of TGA.Takayuki KawaiRyuji SakakibaraYosuke AibaFuyuki TatenoTsuyoshi OgataSetsu SawaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takayuki Kawai Ryuji Sakakibara Yosuke Aiba Fuyuki Tateno Tsuyoshi Ogata Setsu Sawai Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
description	Abstract Oxidative stress may accompany the pathological process in transient global amnesia (TGA). We measured the biological antioxidant potential (BAP) in the cerebrospinal fluid (CSF) of TGA patients. We enrolled 13 TGA patients (7 men, 6 women; mean age 65.0 years [48–70 years]) and 24 control subjects (12 men, 12 women; mean age 38.2 years [17–65 years]; age did not correlate with csfBAP in this group). We performed brain MRI in all TGA patients, and CA1 lesions were noted by MRI in 5 subjects. We measured csfBAP, total antioxidant properties, in all TGA patients and controls. csfBAP levels were higher in TGA patients than in controls (p = 0.024, 0.028). csfBAP levels in TGA patients did not differ between MRI-positive and -negative subgroups. Elevated csfBAP levels were observed in TGA patients, suggesting that oxidative stress may have a role in the pathogenesis of TGA.
format	article
author	Takayuki Kawai Ryuji Sakakibara Yosuke Aiba Fuyuki Tateno Tsuyoshi Ogata Setsu Sawai
author_facet	Takayuki Kawai Ryuji Sakakibara Yosuke Aiba Fuyuki Tateno Tsuyoshi Ogata Setsu Sawai
author_sort	Takayuki Kawai
title	Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_short	Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_full	Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_fullStr	Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_full_unstemmed	Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
title_sort	increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c2c0f9ef6d74f1aa5c5f325ae63a07c
work_keys_str_mv	AT takayukikawai increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients AT ryujisakakibara increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients AT yosukeaiba increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients AT fuyukitateno increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients AT tsuyoshiogata increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients AT setsusawai increasedbiologicalantioxidantpotentialinthecerebrospinalfluidoftransientglobalamnesiapatients
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Increased biological antioxidant potential in the cerebrospinal fluid of transient global amnesia patients

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