Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes

Cells are exposed to shifts in environmental pH, which direct their metabolism and behavior. Here the authors design pH-sensing riboswitches to create a gene expression program, digitalize the system to respond to a narrow pH range and apply it to evolve host cells with improved tolerance to a varie...

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Autores principales:	Hoang Long Pham, Adison Wong, Niying Chua, Wei Suong Teo, Wen Shan Yew, Matthew Wook Chang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c2c92d882484cfb8b1ed9af3d8bee95
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spelling	oai:doaj.org-article:5c2c92d882484cfb8b1ed9af3d8bee952021-12-02T17:06:18ZEngineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes10.1038/s41467-017-00511-w2041-1723https://doaj.org/article/5c2c92d882484cfb8b1ed9af3d8bee952017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00511-whttps://doaj.org/toc/2041-1723Cells are exposed to shifts in environmental pH, which direct their metabolism and behavior. Here the authors design pH-sensing riboswitches to create a gene expression program, digitalize the system to respond to a narrow pH range and apply it to evolve host cells with improved tolerance to a variety of organic acids.Hoang Long PhamAdison WongNiying ChuaWei Suong TeoWen Shan YewMatthew Wook ChangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hoang Long Pham Adison Wong Niying Chua Wei Suong Teo Wen Shan Yew Matthew Wook Chang Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
description	Cells are exposed to shifts in environmental pH, which direct their metabolism and behavior. Here the authors design pH-sensing riboswitches to create a gene expression program, digitalize the system to respond to a narrow pH range and apply it to evolve host cells with improved tolerance to a variety of organic acids.
format	article
author	Hoang Long Pham Adison Wong Niying Chua Wei Suong Teo Wen Shan Yew Matthew Wook Chang
author_facet	Hoang Long Pham Adison Wong Niying Chua Wei Suong Teo Wen Shan Yew Matthew Wook Chang
author_sort	Hoang Long Pham
title	Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
title_short	Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
title_full	Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
title_fullStr	Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
title_full_unstemmed	Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
title_sort	engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5c2c92d882484cfb8b1ed9af3d8bee95
work_keys_str_mv	AT hoanglongpham engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes AT adisonwong engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes AT niyingchua engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes AT weisuongteo engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes AT wenshanyew engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes AT matthewwookchang engineeringariboswitchbasedgeneticplatformfortheselfdirectedevolutionofacidtolerantphenotypes
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Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes

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