Engineering a riboswitch-based genetic platform for the self-directed evolution of acid-tolerant phenotypes

Cells are exposed to shifts in environmental pH, which direct their metabolism and behavior. Here the authors design pH-sensing riboswitches to create a gene expression program, digitalize the system to respond to a narrow pH range and apply it to evolve host cells with improved tolerance to a varie...

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Auteurs principaux: Hoang Long Pham, Adison Wong, Niying Chua, Wei Suong Teo, Wen Shan Yew, Matthew Wook Chang
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/5c2c92d882484cfb8b1ed9af3d8bee95
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