A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil
Myristica fragrans Houtt., commonly known as nutmeg, is an Indonesian indigenous dioecious evergreen tree which contains 5-15% volatile oil. The oil is usually produced from the seed or mace. Nutmeg oil has been extensively utilized in aromatherapy, natural medicine, and the perfume industry. This...
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Universitas Gadjah Mada
2021
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oai:doaj.org-article:5c2db6da3474451cad76108abd1ff23d2021-11-15T06:08:46ZA Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil2338-94272338-948610.22146/ijp.1271https://doaj.org/article/5c2db6da3474451cad76108abd1ff23d2021-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1271https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Myristica fragrans Houtt., commonly known as nutmeg, is an Indonesian indigenous dioecious evergreen tree which contains 5-15% volatile oil. The oil is usually produced from the seed or mace. Nutmeg oil has been extensively utilized in aromatherapy, natural medicine, and the perfume industry. This article provides an overview of the chemical compounds, biological potency, and toxic effects of nutmeg essential oil compiled from recent literature (2000–2020). Nutmeg oil mainly comprises monoterpenes and phenylpropanoids. Several reports on gas chromatography-mass spectrophotometry analysis of nutmeg oil showed that there were 27–38 chemical constituents detected at various concentrations. Many secondary metabolites of nutmeg oil reported to show biological activities that possibly substantiate its utilization in natural medicine. Numerous studies reported the biological activities of this volatile oil such as antioxidant, analgesic, antiinflammation, anticonvulsant, antibacterial, antiparasitic, insecticidal, and anticancer activity. But large intake of nutmeg oil could cause intoxication which is shown through symptoms in cardiovascular, central nervous system, anticholinergic, and local effects in the stomach. These symptoms are mainly attributed to the effect of myristicin, safrole, and elemicin overdose. This updated review paper intends to attract more attention to nutmeg oil and its potential to be developed into a medicinal product for the prophylaxis and therapy of diseases.Mega Ferdina WarsitoUniversitas Gadjah Madaarticlenutmeg, volatile oil, chemical composition, bioactivity, toxicityPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 304-313 (2021) |
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DOAJ |
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nutmeg, volatile oil, chemical composition, bioactivity, toxicity Pharmacy and materia medica RS1-441 |
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nutmeg, volatile oil, chemical composition, bioactivity, toxicity Pharmacy and materia medica RS1-441 Mega Ferdina Warsito A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| description |
Myristica fragrans Houtt., commonly known as nutmeg, is an Indonesian indigenous dioecious evergreen tree which contains 5-15% volatile oil. The oil is usually produced from the seed or mace. Nutmeg oil has been extensively utilized in aromatherapy, natural medicine, and the perfume industry. This article provides an overview of the chemical compounds, biological potency, and toxic effects of nutmeg essential oil compiled from recent literature (2000–2020). Nutmeg oil mainly comprises monoterpenes and phenylpropanoids. Several reports on gas chromatography-mass spectrophotometry analysis of nutmeg oil showed that there were 27–38 chemical constituents detected at various concentrations. Many secondary metabolites of nutmeg oil reported to show biological activities that possibly substantiate its utilization in natural medicine. Numerous studies reported the biological activities of this volatile oil such as antioxidant, analgesic, antiinflammation, anticonvulsant, antibacterial, antiparasitic, insecticidal, and anticancer activity. But large intake of nutmeg oil could cause intoxication which is shown through symptoms in cardiovascular, central nervous system, anticholinergic, and local effects in the stomach. These symptoms are mainly attributed to the effect of myristicin, safrole, and elemicin overdose. This updated review paper intends to attract more attention to nutmeg oil and its potential to be developed into a medicinal product for the prophylaxis and therapy of diseases. |
| format |
article |
| author |
Mega Ferdina Warsito |
| author_facet |
Mega Ferdina Warsito |
| author_sort |
Mega Ferdina Warsito |
| title |
A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| title_short |
A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| title_full |
A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| title_fullStr |
A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| title_full_unstemmed |
A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil |
| title_sort |
review on chemical composition, bioactivity, and toxicity of myristica fragrans houtt. essential oil |
| publisher |
Universitas Gadjah Mada |
| publishDate |
2021 |
| url |
https://doaj.org/article/5c2db6da3474451cad76108abd1ff23d |
| work_keys_str_mv |
AT megaferdinawarsito areviewonchemicalcompositionbioactivityandtoxicityofmyristicafragranshouttessentialoil AT megaferdinawarsito reviewonchemicalcompositionbioactivityandtoxicityofmyristicafragranshouttessentialoil |
| _version_ |
1718428553741074432 |