Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration

Abstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by...

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Autores principales:	Giuseppe Querques, Riccardo Sacconi, Francesco Gelormini, Enrico Borrelli, Francesco Prascina, Ilaria Zucchiatti, Lea Querques, Francesco Bandello
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c30f1b6e3f74e97aebf3b48a4ccd959
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spelling	oai:doaj.org-article:5c30f1b6e3f74e97aebf3b48a4ccd9592021-12-02T10:48:13ZSubthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration10.1038/s41598-021-81810-72045-2322https://doaj.org/article/5c30f1b6e3f74e97aebf3b48a4ccd9592021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81810-7https://doaj.org/toc/2045-2322Abstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by RPD secondary to dry AMD (dAMD). Twenty eyes of 20 patients (mean age 78.4 ± 6.8 years) with RPD secondary to dAMD were prospectively enrolled. All patients were treated in an extrafoveal area of 1.27 mm2 using end-point management yellow subthreshold laser and followed for 3 months. Best-corrected visual acuity was 0.140 ± 0.09 LogMAR at the baseline and no changes were observed during the follow-up (p = 0.232). No significant worsening was disclosed before and after the treatment analyzing the macular sensitivity of the treated area (p = 0.152). No topical and/or systemic side effects were disclosed during the 3-month follow-up. The distribution among the RPD stages changed after the treatment (p < 0.001). In detail, in the treated area, we observed a significant increase in the number of Stage 1 RPD during the follow-up (p = 0.002), associated with a significant decrease of Stage 3 RPD (p = 0.020). Outer nuclear layer (ONL) thickness analysis showed a significant increase after the treatment associated with RPD regression (p = 0.001). End-point management SLT appears a safe treatment for RPD secondary to dAMD, showing short-term safety outcomes. Our results suggest that SLT could be effective in inducing a RPD regression in terms of RPD stage and ONL thickening.Giuseppe QuerquesRiccardo SacconiFrancesco GelorminiEnrico BorrelliFrancesco PrascinaIlaria ZucchiattiLea QuerquesFrancesco BandelloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
description	Abstract There is a lack of treatment aimed at the regression of reticular pseudodrusen (RPD) secondary to age-related macular degeneration (AMD). The aim of this prospective, pilot study is to evaluate the safety and short-term efficacy of subthreshold laser treatment (SLT) in patients affected by RPD secondary to dry AMD (dAMD). Twenty eyes of 20 patients (mean age 78.4 ± 6.8 years) with RPD secondary to dAMD were prospectively enrolled. All patients were treated in an extrafoveal area of 1.27 mm2 using end-point management yellow subthreshold laser and followed for 3 months. Best-corrected visual acuity was 0.140 ± 0.09 LogMAR at the baseline and no changes were observed during the follow-up (p = 0.232). No significant worsening was disclosed before and after the treatment analyzing the macular sensitivity of the treated area (p = 0.152). No topical and/or systemic side effects were disclosed during the 3-month follow-up. The distribution among the RPD stages changed after the treatment (p < 0.001). In detail, in the treated area, we observed a significant increase in the number of Stage 1 RPD during the follow-up (p = 0.002), associated with a significant decrease of Stage 3 RPD (p = 0.020). Outer nuclear layer (ONL) thickness analysis showed a significant increase after the treatment associated with RPD regression (p = 0.001). End-point management SLT appears a safe treatment for RPD secondary to dAMD, showing short-term safety outcomes. Our results suggest that SLT could be effective in inducing a RPD regression in terms of RPD stage and ONL thickening.
format	article
author	Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello
author_facet	Giuseppe Querques Riccardo Sacconi Francesco Gelormini Enrico Borrelli Francesco Prascina Ilaria Zucchiatti Lea Querques Francesco Bandello
author_sort	Giuseppe Querques
title	Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
title_short	Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
title_full	Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
title_fullStr	Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
title_full_unstemmed	Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
title_sort	subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c30f1b6e3f74e97aebf3b48a4ccd959
work_keys_str_mv	AT giuseppequerques subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT riccardosacconi subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT francescogelormini subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT enricoborrelli subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT francescoprascina subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT ilariazucchiatti subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT leaquerques subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration AT francescobandello subthresholdlasertreatmentforreticularpseudodrusensecondarytoagerelatedmaculardegeneration
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Subthreshold laser treatment for reticular pseudodrusen secondary to age-related macular degeneration

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