Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I restricted mutant KRAS G12 peptides, leading to t...

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Autores principales:	Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Scholler, Avery D. Posey, Mark H. O’Hara, Anze Smole, Daniel J. Powell, Benjamin A. Garcia, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c32458bd77b40989a4cd89c57021223
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spelling	oai:doaj.org-article:5c32458bd77b40989a4cd89c570212232021-12-02T18:36:59ZBiochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting10.1038/s41467-021-24562-22041-1723https://doaj.org/article/5c32458bd77b40989a4cd89c570212232021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24562-2https://doaj.org/toc/2041-1723KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I restricted mutant KRAS G12 peptides, leading to the generation of mutant KRAS-specific T cell receptors for adoptive T cell immunotherapy.Adham S. BearTatiana BlanchardJoseph CesareMichael J. FordLee P. RichmanChong XuMiren L. BarojaSarah McCuaigChristina CosteasKhatuna GabuniaJohn SchollerAvery D. PoseyMark H. O’HaraAnze SmoleDaniel J. PowellBenjamin A. GarciaRobert H. VonderheideGerald P. LinetteBeatriz M. CarrenoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adham S. Bear Tatiana Blanchard Joseph Cesare Michael J. Ford Lee P. Richman Chong Xu Miren L. Baroja Sarah McCuaig Christina Costeas Khatuna Gabunia John Scholler Avery D. Posey Mark H. O’Hara Anze Smole Daniel J. Powell Benjamin A. Garcia Robert H. Vonderheide Gerald P. Linette Beatriz M. Carreno Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
description	KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I restricted mutant KRAS G12 peptides, leading to the generation of mutant KRAS-specific T cell receptors for adoptive T cell immunotherapy.
format	article
author	Adham S. Bear Tatiana Blanchard Joseph Cesare Michael J. Ford Lee P. Richman Chong Xu Miren L. Baroja Sarah McCuaig Christina Costeas Khatuna Gabunia John Scholler Avery D. Posey Mark H. O’Hara Anze Smole Daniel J. Powell Benjamin A. Garcia Robert H. Vonderheide Gerald P. Linette Beatriz M. Carreno
author_facet	Adham S. Bear Tatiana Blanchard Joseph Cesare Michael J. Ford Lee P. Richman Chong Xu Miren L. Baroja Sarah McCuaig Christina Costeas Khatuna Gabunia John Scholler Avery D. Posey Mark H. O’Hara Anze Smole Daniel J. Powell Benjamin A. Garcia Robert H. Vonderheide Gerald P. Linette Beatriz M. Carreno
author_sort	Adham S. Bear
title	Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
title_short	Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
title_full	Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
title_fullStr	Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
title_full_unstemmed	Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting
title_sort	biochemical and functional characterization of mutant kras epitopes validates this oncoprotein for immunological targeting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c32458bd77b40989a4cd89c57021223
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Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting

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