Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.

The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yasutaka Mizoro, Yoshiaki Yamaguchi, Rena Kitazawa, Hiroyuki Yamada, Masahiro Matsuo, Jean-Michel Fustin, Masao Doi, Hitoshi Okamura
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c3456f4b939437eb8614b85cbd2ecf9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c3456f4b939437eb8614b85cbd2ecf9
record_format	dspace
spelling	oai:doaj.org-article:5c3456f4b939437eb8614b85cbd2ecf92021-12-02T20:21:11ZActivation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.1932-620310.1371/journal.pone.0010951https://doaj.org/article/5c3456f4b939437eb8614b85cbd2ecf92010-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20532181/?tool=EBIhttps://doaj.org/toc/1932-6203The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN.Yasutaka MizoroYoshiaki YamaguchiRena KitazawaHiroyuki YamadaMasahiro MatsuoJean-Michel FustinMasao DoiHitoshi OkamuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 6, p e10951 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasutaka Mizoro Yoshiaki Yamaguchi Rena Kitazawa Hiroyuki Yamada Masahiro Matsuo Jean-Michel Fustin Masao Doi Hitoshi Okamura Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
description	The glutamatergic neurotransmission in the suprachiasmatic nucleus (SCN) plays a central role in the entrainment of the circadian rhythms to environmental light-dark cycles. Although the glutamatergic effect operating via NMDAR (N-methyl D-aspartate receptor) is well elucidated, much less is known about a role of AMPAR (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor) in circadian entrainment. Here we show that, in the mouse SCN, GluR2 and GluR4 AMPAR subtypes are abundantly expressed in the retinorecipient area. In vivo microinjection of AMPA in the SCN during the early subjective night phase-delays the behavioral rhythm. In the organotypic SCN slice culture, AMPA application induces phase-dependent phase-shifts of core-clock gene transcription rhythms. These data demonstrate that activation of AMPAR is capable of phase-shifting the circadian clock both in vivo and in vitro, and are consistent with the hypothesis that activation of AMPA receptors is a critical step in the transmission of photic information to the SCN.
format	article
author	Yasutaka Mizoro Yoshiaki Yamaguchi Rena Kitazawa Hiroyuki Yamada Masahiro Matsuo Jean-Michel Fustin Masao Doi Hitoshi Okamura
author_facet	Yasutaka Mizoro Yoshiaki Yamaguchi Rena Kitazawa Hiroyuki Yamada Masahiro Matsuo Jean-Michel Fustin Masao Doi Hitoshi Okamura
author_sort	Yasutaka Mizoro
title	Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
title_short	Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
title_full	Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
title_fullStr	Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
title_full_unstemmed	Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
title_sort	activation of ampa receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/5c3456f4b939437eb8614b85cbd2ecf9
work_keys_str_mv	AT yasutakamizoro activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT yoshiakiyamaguchi activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT renakitazawa activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT hiroyukiyamada activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT masahiromatsuo activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT jeanmichelfustin activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT masaodoi activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro AT hitoshiokamura activationofampareceptorsinthesuprachiasmaticnucleusphaseshiftsthemousecircadianclockinvivoandinvitro
_version_	1718374109040082944

Activation of AMPA receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitro.

Ejemplares similares