Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

Primordial Germ Cell-Like Cells (PGCLCs) are an in vitro model for primordial germ cell development. Here, the authors couple a novel compound reporter with CRISPR screening to identify key genes for exit from pluripotency and acquisition of PGCLC fate; specifically identifying Nr5a2 and Zfp296.

Guardado en:

Detalles Bibliográficos
Autores principales:	Jamie A. Hackett, Yun Huang, Ufuk Günesdogan, Kristjan A. Gretarsson, Toshihiro Kobayashi, M. Azim Surani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c34654d52b24b38beedd6ab9c107982
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c34654d52b24b38beedd6ab9c107982
record_format	dspace
spelling	oai:doaj.org-article:5c34654d52b24b38beedd6ab9c1079822021-12-02T15:34:23ZTracing the transitions from pluripotency to germ cell fate with CRISPR screening10.1038/s41467-018-06230-02041-1723https://doaj.org/article/5c34654d52b24b38beedd6ab9c1079822018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06230-0https://doaj.org/toc/2041-1723Primordial Germ Cell-Like Cells (PGCLCs) are an in vitro model for primordial germ cell development. Here, the authors couple a novel compound reporter with CRISPR screening to identify key genes for exit from pluripotency and acquisition of PGCLC fate; specifically identifying Nr5a2 and Zfp296.Jamie A. HackettYun HuangUfuk GünesdoganKristjan A. GretarssonToshihiro KobayashiM. Azim SuraniNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jamie A. Hackett Yun Huang Ufuk Günesdogan Kristjan A. Gretarsson Toshihiro Kobayashi M. Azim Surani Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
description	Primordial Germ Cell-Like Cells (PGCLCs) are an in vitro model for primordial germ cell development. Here, the authors couple a novel compound reporter with CRISPR screening to identify key genes for exit from pluripotency and acquisition of PGCLC fate; specifically identifying Nr5a2 and Zfp296.
format	article
author	Jamie A. Hackett Yun Huang Ufuk Günesdogan Kristjan A. Gretarsson Toshihiro Kobayashi M. Azim Surani
author_facet	Jamie A. Hackett Yun Huang Ufuk Günesdogan Kristjan A. Gretarsson Toshihiro Kobayashi M. Azim Surani
author_sort	Jamie A. Hackett
title	Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
title_short	Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
title_full	Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
title_fullStr	Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
title_full_unstemmed	Tracing the transitions from pluripotency to germ cell fate with CRISPR screening
title_sort	tracing the transitions from pluripotency to germ cell fate with crispr screening
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5c34654d52b24b38beedd6ab9c107982
work_keys_str_mv	AT jamieahackett tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening AT yunhuang tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening AT ufukgunesdogan tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening AT kristjanagretarsson tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening AT toshihirokobayashi tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening AT mazimsurani tracingthetransitionsfrompluripotencytogermcellfatewithcrisprscreening
_version_	1718386838495821824

Tracing the transitions from pluripotency to germ cell fate with CRISPR screening

Ejemplares similares