Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study

Abstract The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study e...

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Autores principales:	Guanjian Li, Ke Sun, Jie Guo, Shixing Li, Bo Li, Jing Cao, Pengfei Lu, Jiajia Yang, Ying Zhang, Xin Yang, Le Gao, Yi He, Tao Cui, Bin Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c38dd54e6f544a78063c2493a254cae
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spelling	oai:doaj.org-article:5c38dd54e6f544a78063c2493a254cae2021-12-02T11:51:13ZPrognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study10.1038/s41598-017-05638-w2045-2322https://doaj.org/article/5c38dd54e6f544a78063c2493a254cae2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05638-whttps://doaj.org/toc/2045-2322Abstract The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic significance of digit ratio in prostate cancer patients. We reviewed the progressive status and survival of 382 prostate cancer patients who had received hormone therapy at our institutions. Survival of clinicopathological variables analyzed as categorical variables were determined by the log-rank test. According to Cox’s proportional hazards analysis, R2D:4D, L2D:4D, PSA at 6 month,bone metastasis were significant independent factors for prostate cancer. The risk of any progression of prostate cancer similarly depressed with increasing 2D:4D, for any progression (R2D:4D HR = 0.71, p = 0.003; L2D:4D HR = 0.67, p = 0.001), for cancer-specific death (R2D:4D HR = 0.67, p = 0.025; L2D:4D HR = 0.74, p = 0.036). Digit ratio may not only have predictive value in risk but also prognosis of prostatic cancer. This finding suggests that low 2D:4D can be used as prognostic factors to identify patients with a poor prognosis. These patients may benefit from more aggressive management.Guanjian LiKe SunJie GuoShixing LiBo LiJing CaoPengfei LuJiajia YangYing ZhangXin YangLe GaoYi HeTao CuiBin MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guanjian Li Ke Sun Jie Guo Shixing Li Bo Li Jing Cao Pengfei Lu Jiajia Yang Ying Zhang Xin Yang Le Gao Yi He Tao Cui Bin Ma Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
description	Abstract The digit ratio has been used as a retrospective noninvasive biomarker to investigate the putative effects of prenatal exposure to androgens. In recent years, many scholars have paid attention to the association between 2D:4D (the second and fourth digits) and prostatic cancer. This study explored the prognostic significance of digit ratio in prostate cancer patients. We reviewed the progressive status and survival of 382 prostate cancer patients who had received hormone therapy at our institutions. Survival of clinicopathological variables analyzed as categorical variables were determined by the log-rank test. According to Cox’s proportional hazards analysis, R2D:4D, L2D:4D, PSA at 6 month,bone metastasis were significant independent factors for prostate cancer. The risk of any progression of prostate cancer similarly depressed with increasing 2D:4D, for any progression (R2D:4D HR = 0.71, p = 0.003; L2D:4D HR = 0.67, p = 0.001), for cancer-specific death (R2D:4D HR = 0.67, p = 0.025; L2D:4D HR = 0.74, p = 0.036). Digit ratio may not only have predictive value in risk but also prognosis of prostatic cancer. This finding suggests that low 2D:4D can be used as prognostic factors to identify patients with a poor prognosis. These patients may benefit from more aggressive management.
format	article
author	Guanjian Li Ke Sun Jie Guo Shixing Li Bo Li Jing Cao Pengfei Lu Jiajia Yang Ying Zhang Xin Yang Le Gao Yi He Tao Cui Bin Ma
author_facet	Guanjian Li Ke Sun Jie Guo Shixing Li Bo Li Jing Cao Pengfei Lu Jiajia Yang Ying Zhang Xin Yang Le Gao Yi He Tao Cui Bin Ma
author_sort	Guanjian Li
title	Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
title_short	Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
title_full	Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
title_fullStr	Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
title_full_unstemmed	Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
title_sort	prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5c38dd54e6f544a78063c2493a254cae
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Prognostic significance of the digit ratio after hormone therapy for prostate cancer: a prospective multicenter study

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