Microbial metabolite sensor GPR43 controls severity of experimental GVHD

The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.

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Detalles Bibliográficos
Autores principales: Hideaki Fujiwara, Melissa D. Docampo, Mary Riwes, Daniel Peltier, Tomomi Toubai, Israel Henig, S. Julia Wu, Stephanie Kim, Austin Taylor, Stuart Brabbs, Chen Liu, Cynthia Zajac, Katherine Oravecz-Wilson, Yaping Sun, Gabriel Núñez, John E. Levine, Marcel R.M. van den Brink, James L. M. Ferrara, Pavan Reddy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5c3db952590146dbaba8c347ece59caa
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Sumario:The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD.