Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak

Abstract A combination of magnetic resonance imaging (MRI), computed tomography (CT), and radionuclide cisternography are typically used to locate a cerebrospinal fluid (CSF) leak. However, the site of leakage cannot be determined, making treatment more difficult. Therefore, more sensitive imaging t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daehyun Yoon, Peter William Cipriano, Ryan Penticuff, Jessa Ballesteros Castillo, Yingding Xu, Ian Richard Carroll, Sandip Biswal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c3edd4980de4730b970600aeae88553
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c3edd4980de4730b970600aeae88553
record_format	dspace
spelling	oai:doaj.org-article:5c3edd4980de4730b970600aeae885532021-12-02T14:53:49ZAbnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak10.1038/s41598-021-95056-w2045-2322https://doaj.org/article/5c3edd4980de4730b970600aeae885532021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95056-whttps://doaj.org/toc/2045-2322Abstract A combination of magnetic resonance imaging (MRI), computed tomography (CT), and radionuclide cisternography are typically used to locate a cerebrospinal fluid (CSF) leak. However, the site of leakage cannot be determined, making treatment more difficult. Therefore, more sensitive imaging tools are needed. A whole-body [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI was conducted on six patients with suspected CSF leak and the resulting images were reviewed in comparison with those from six healthy controls. Paraspinal regions of focally increased uptake of [18F]FDG were quantified using maximum standardized uptake values (SUVmax) and compared to the SUVmax of corresponding regions in the healthy controls. All six patients with suspected CSF leak showed paraspinal regions of significantly greater [18F]FDG uptake compared to the corresponding areas in controls (P < 0.05). Two patients treated with local injections (epidural blood patches and/or epidural fibrin patches) on the site of abnormal PET/MRI findings reported temporary but significant improvement in symptoms. Our results suggest [18F]FDG PET/MRI is sensitive to abnormalities potentially due to suspected CSF leak, which are not necessarily visible on conventional MRI alone or by the standard-of-care imaging methods.Daehyun YoonPeter William CiprianoRyan PenticuffJessa Ballesteros CastilloYingding XuIan Richard CarrollSandip BiswalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daehyun Yoon Peter William Cipriano Ryan Penticuff Jessa Ballesteros Castillo Yingding Xu Ian Richard Carroll Sandip Biswal Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
description	Abstract A combination of magnetic resonance imaging (MRI), computed tomography (CT), and radionuclide cisternography are typically used to locate a cerebrospinal fluid (CSF) leak. However, the site of leakage cannot be determined, making treatment more difficult. Therefore, more sensitive imaging tools are needed. A whole-body [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/MRI was conducted on six patients with suspected CSF leak and the resulting images were reviewed in comparison with those from six healthy controls. Paraspinal regions of focally increased uptake of [18F]FDG were quantified using maximum standardized uptake values (SUVmax) and compared to the SUVmax of corresponding regions in the healthy controls. All six patients with suspected CSF leak showed paraspinal regions of significantly greater [18F]FDG uptake compared to the corresponding areas in controls (P < 0.05). Two patients treated with local injections (epidural blood patches and/or epidural fibrin patches) on the site of abnormal PET/MRI findings reported temporary but significant improvement in symptoms. Our results suggest [18F]FDG PET/MRI is sensitive to abnormalities potentially due to suspected CSF leak, which are not necessarily visible on conventional MRI alone or by the standard-of-care imaging methods.
format	article
author	Daehyun Yoon Peter William Cipriano Ryan Penticuff Jessa Ballesteros Castillo Yingding Xu Ian Richard Carroll Sandip Biswal
author_facet	Daehyun Yoon Peter William Cipriano Ryan Penticuff Jessa Ballesteros Castillo Yingding Xu Ian Richard Carroll Sandip Biswal
author_sort	Daehyun Yoon
title	Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
title_short	Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
title_full	Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
title_fullStr	Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
title_full_unstemmed	Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
title_sort	abnormal [18f]fdg pet/mri findings in paraspinal structures of patients with suspected cerebrospinal fluid leak
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c3edd4980de4730b970600aeae88553
work_keys_str_mv	AT daehyunyoon abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT peterwilliamcipriano abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT ryanpenticuff abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT jessaballesteroscastillo abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT yingdingxu abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT ianrichardcarroll abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak AT sandipbiswal abnormal18ffdgpetmrifindingsinparaspinalstructuresofpatientswithsuspectedcerebrospinalfluidleak
_version_	1718389386509287424

Abnormal [18F]FDG PET/MRI findings in paraspinal structures of patients with suspected cerebrospinal fluid leak

Ejemplares similares