Influence of a multicomponent plant substance on physical endurance in the forced swimming test

The effect of preventive administration of the complex phytopreparation "tetraphyton" has been studied in experiments on rats. Tetraphyton developed on the base of Tibetan formula is the dry extract derived from species of plant material: roots of Inula helenium L., roots of Zingiber offic...

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Autores principales:	E. A. Alekseeva, O. G. Dimitrov, L. N. Shantanova, B. A. Muruev, A. A. Toropova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	phytopreparation actoprotective activity tetraphyton rats antioxidants Science Q
Acceso en línea:	https://doaj.org/article/5c3f2b3733724044b008c8e34bbea714
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spelling	oai:doaj.org-article:5c3f2b3733724044b008c8e34bbea7142021-11-23T06:14:40ZInfluence of a multicomponent plant substance on physical endurance in the forced swimming test2541-94202587-959610.29413/ABS.2018-3.2.17https://doaj.org/article/5c3f2b3733724044b008c8e34bbea7142018-04-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/567https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The effect of preventive administration of the complex phytopreparation "tetraphyton" has been studied in experiments on rats. Tetraphyton developed on the base of Tibetan formula is the dry extract derived from species of plant material: roots of Inula helenium L., roots of Zingiber officinale Roscoe, fruits of Elletaria cardamomum (L.) Maton, offshoots of Caragana spinosa (L.) Wall. ex Hornem., characterized for the content of phenolic compounds, flavonoids, terpenoids. The preventive course introduction of tetraphyton in a dose 100 mg/kg for 7 days before experiment increases the potential for physical performance, increasing overall physical endurance against a background of intense physical exertion by 73 % (p < 0.05), prevents fatigue. It is shown that increase in the physical performance of rats in the experimental group is due to increase in the efficiency of the energy supply system in skeletal muscles and myocardium: a significant increase in the content of ATP (by 13 % and 2.5 times); decrease in lactate and pyruvate content (by 33 and 30 %; p < 0.05); increased glycogen content in the liver by 23 %, blood glucose by 19 %. The increase in catalase, SOD, and gSh levels (5 %, 19 %, 79 %; p < 0.05) indicates an increase in the power of the antioxidant defense of the organism and causes the cytoprotective effect of tetraphyton, confirmed by a decrease in fermentemia (lactate dehydrogenase, kreatinphosphokinase - 49 % and 43 %; p < 0.05). The main molecular-cellular mechanisms of the actoprotective action of the phytoadaptogen is the inhibition of the lipid peroxidation of cell membranes and a significant increase in the capacity of the endogenous antioxidant enzyme system that promotes the preservation of the integrity of skeletal muscles and the myocardium. This is due to the presence of phenolic compounds in the chemical composition that have direct antiradical action and increase the power endogenous antioxidant system.E. A. AlekseevaO. G. DimitrovL. N. ShantanovaB. A. MuruevA. A. ToropovaScientific Сentre for Family Health and Human Reproduction Problemsarticlephytopreparationactoprotective activitytetraphytonratsantioxidantsScienceQRUActa Biomedica Scientifica, Vol 3, Iss 2, Pp 97-101 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	phytopreparation actoprotective activity tetraphyton rats antioxidants Science Q
spellingShingle	phytopreparation actoprotective activity tetraphyton rats antioxidants Science Q E. A. Alekseeva O. G. Dimitrov L. N. Shantanova B. A. Muruev A. A. Toropova Influence of a multicomponent plant substance on physical endurance in the forced swimming test
description	The effect of preventive administration of the complex phytopreparation "tetraphyton" has been studied in experiments on rats. Tetraphyton developed on the base of Tibetan formula is the dry extract derived from species of plant material: roots of Inula helenium L., roots of Zingiber officinale Roscoe, fruits of Elletaria cardamomum (L.) Maton, offshoots of Caragana spinosa (L.) Wall. ex Hornem., characterized for the content of phenolic compounds, flavonoids, terpenoids. The preventive course introduction of tetraphyton in a dose 100 mg/kg for 7 days before experiment increases the potential for physical performance, increasing overall physical endurance against a background of intense physical exertion by 73 % (p < 0.05), prevents fatigue. It is shown that increase in the physical performance of rats in the experimental group is due to increase in the efficiency of the energy supply system in skeletal muscles and myocardium: a significant increase in the content of ATP (by 13 % and 2.5 times); decrease in lactate and pyruvate content (by 33 and 30 %; p < 0.05); increased glycogen content in the liver by 23 %, blood glucose by 19 %. The increase in catalase, SOD, and gSh levels (5 %, 19 %, 79 %; p < 0.05) indicates an increase in the power of the antioxidant defense of the organism and causes the cytoprotective effect of tetraphyton, confirmed by a decrease in fermentemia (lactate dehydrogenase, kreatinphosphokinase - 49 % and 43 %; p < 0.05). The main molecular-cellular mechanisms of the actoprotective action of the phytoadaptogen is the inhibition of the lipid peroxidation of cell membranes and a significant increase in the capacity of the endogenous antioxidant enzyme system that promotes the preservation of the integrity of skeletal muscles and the myocardium. This is due to the presence of phenolic compounds in the chemical composition that have direct antiradical action and increase the power endogenous antioxidant system.
format	article
author	E. A. Alekseeva O. G. Dimitrov L. N. Shantanova B. A. Muruev A. A. Toropova
author_facet	E. A. Alekseeva O. G. Dimitrov L. N. Shantanova B. A. Muruev A. A. Toropova
author_sort	E. A. Alekseeva
title	Influence of a multicomponent plant substance on physical endurance in the forced swimming test
title_short	Influence of a multicomponent plant substance on physical endurance in the forced swimming test
title_full	Influence of a multicomponent plant substance on physical endurance in the forced swimming test
title_fullStr	Influence of a multicomponent plant substance on physical endurance in the forced swimming test
title_full_unstemmed	Influence of a multicomponent plant substance on physical endurance in the forced swimming test
title_sort	influence of a multicomponent plant substance on physical endurance in the forced swimming test
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/5c3f2b3733724044b008c8e34bbea714
work_keys_str_mv	AT eaalekseeva influenceofamulticomponentplantsubstanceonphysicalenduranceintheforcedswimmingtest AT ogdimitrov influenceofamulticomponentplantsubstanceonphysicalenduranceintheforcedswimmingtest AT lnshantanova influenceofamulticomponentplantsubstanceonphysicalenduranceintheforcedswimmingtest AT bamuruev influenceofamulticomponentplantsubstanceonphysicalenduranceintheforcedswimmingtest AT aatoropova influenceofamulticomponentplantsubstanceonphysicalenduranceintheforcedswimmingtest
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Influence of a multicomponent plant substance on physical endurance in the forced swimming test

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