Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.

<h4>Background and objectives</h4>Hypertension represents a major cause of cardiovascular morbidity and mortality worldwide but its prevalence has been shown to vary in different countries. The reasons for such differences are still matter of debate, the relative contributions given by e...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ginevra Biino, Gianfranco Parati, Maria Pina Concas, Mauro Adamo, Andrea Angius, Simona Vaccargiu, Mario Pirastu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c3f49b0a6c94621b4b2e3818e528944
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c3f49b0a6c94621b4b2e3818e528944
record_format	dspace
spelling	oai:doaj.org-article:5c3f49b0a6c94621b4b2e3818e5289442021-11-18T07:52:38ZEnvironmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.1932-620310.1371/journal.pone.0059612https://doaj.org/article/5c3f49b0a6c94621b4b2e3818e5289442013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23527229/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and objectives</h4>Hypertension represents a major cause of cardiovascular morbidity and mortality worldwide but its prevalence has been shown to vary in different countries. The reasons for such differences are still matter of debate, the relative contributions given by environmental and genetic factors being still poorly defined. We estimated the current prevalence, distribution and determinants of hypertension in isolated Sardinian populations and also investigated the environmental and genetic contribution to hypertension prevalence taking advantage of the characteristics of such populations.<h4>Methods and results</h4>An epidemiological survey with cross-sectional design was carried out measuring blood pressure in 9845 inhabitants of 10 villages of Ogliastra region between 2002 and 2008. Regression analysis for assessing blood pressure determinants and variance component models for estimating heritability were performed. Overall 38.8% of this population had hypertension, its prevalence varying significantly by age, sex and among villages taking into account age and sex structure of their population. About 50% of hypertensives had prior cardiovascular disease. High blood pressure was independently associated with age, obesity related factors, heart rate, total cholesterol, alcohol consumption, low education and smoking status, all these factors contributing more in women than in men. Heritability was 27% for diastolic and 36% for systolic blood pressure, its contribution being significantly higher in men (57%) than in women (46%). Finally, the genetic correlation between systolic and diastolic blood pressure was 0.74, indicating incomplete pleiotropy.<h4>Conclusion</h4>Genetic factors involved in the expression of blood pressure traits account for about 30% of the phenotypic variance, but seem to play a larger role in men; comorbidities and environmental factors remain of predominant importance, but seem to contribute much more in women.Ginevra BiinoGianfranco ParatiMaria Pina ConcasMauro AdamoAndrea AngiusAndrea AngiusSimona VaccargiuMario PirastuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 3, p e59612 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ginevra Biino Gianfranco Parati Maria Pina Concas Mauro Adamo Andrea Angius Andrea Angius Simona Vaccargiu Mario Pirastu Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
description	<h4>Background and objectives</h4>Hypertension represents a major cause of cardiovascular morbidity and mortality worldwide but its prevalence has been shown to vary in different countries. The reasons for such differences are still matter of debate, the relative contributions given by environmental and genetic factors being still poorly defined. We estimated the current prevalence, distribution and determinants of hypertension in isolated Sardinian populations and also investigated the environmental and genetic contribution to hypertension prevalence taking advantage of the characteristics of such populations.<h4>Methods and results</h4>An epidemiological survey with cross-sectional design was carried out measuring blood pressure in 9845 inhabitants of 10 villages of Ogliastra region between 2002 and 2008. Regression analysis for assessing blood pressure determinants and variance component models for estimating heritability were performed. Overall 38.8% of this population had hypertension, its prevalence varying significantly by age, sex and among villages taking into account age and sex structure of their population. About 50% of hypertensives had prior cardiovascular disease. High blood pressure was independently associated with age, obesity related factors, heart rate, total cholesterol, alcohol consumption, low education and smoking status, all these factors contributing more in women than in men. Heritability was 27% for diastolic and 36% for systolic blood pressure, its contribution being significantly higher in men (57%) than in women (46%). Finally, the genetic correlation between systolic and diastolic blood pressure was 0.74, indicating incomplete pleiotropy.<h4>Conclusion</h4>Genetic factors involved in the expression of blood pressure traits account for about 30% of the phenotypic variance, but seem to play a larger role in men; comorbidities and environmental factors remain of predominant importance, but seem to contribute much more in women.
format	article
author	Ginevra Biino Gianfranco Parati Maria Pina Concas Mauro Adamo Andrea Angius Andrea Angius Simona Vaccargiu Mario Pirastu
author_facet	Ginevra Biino Gianfranco Parati Maria Pina Concas Mauro Adamo Andrea Angius Andrea Angius Simona Vaccargiu Mario Pirastu
author_sort	Ginevra Biino
title	Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
title_short	Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
title_full	Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
title_fullStr	Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
title_full_unstemmed	Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.
title_sort	environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on sardinian genetic isolates.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/5c3f49b0a6c94621b4b2e3818e528944
work_keys_str_mv	AT ginevrabiino environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT gianfrancoparati environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT mariapinaconcas environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT mauroadamo environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT andreaangius environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT andreaangius environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT simonavaccargiu environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates AT mariopirastu environmentalandgeneticcontributiontohypertensionprevalencedatafromanepidemiologicalsurveyonsardiniangeneticisolates
_version_	1718422814011162624

Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.

Ejemplares similares