Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

Ebola virus (EBOV) VP30 is a multifunctional protein that plays a role in transcription, but molecular details remain unknown. Here, using X-ray crystallography and minigenome assays, Xuet al. define the interaction between VP30 and a portion of NP that is critical for optimal EBOV RNA synthesis.

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Autores principales:	Wei Xu, Priya Luthra, Chao Wu, Jyoti Batra, Daisy W. Leung, Christopher F. Basler, Gaya K. Amarasinghe
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c4091a760484f9a90a55306fceabb20
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spelling	oai:doaj.org-article:5c4091a760484f9a90a55306fceabb202021-12-02T15:37:00ZEbola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis10.1038/ncomms155762041-1723https://doaj.org/article/5c4091a760484f9a90a55306fceabb202017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15576https://doaj.org/toc/2041-1723Ebola virus (EBOV) VP30 is a multifunctional protein that plays a role in transcription, but molecular details remain unknown. Here, using X-ray crystallography and minigenome assays, Xuet al. define the interaction between VP30 and a portion of NP that is critical for optimal EBOV RNA synthesis.Wei XuPriya LuthraChao WuJyoti BatraDaisy W. LeungChristopher F. BaslerGaya K. AmarasingheNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Xu Priya Luthra Chao Wu Jyoti Batra Daisy W. Leung Christopher F. Basler Gaya K. Amarasinghe Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
description	Ebola virus (EBOV) VP30 is a multifunctional protein that plays a role in transcription, but molecular details remain unknown. Here, using X-ray crystallography and minigenome assays, Xuet al. define the interaction between VP30 and a portion of NP that is critical for optimal EBOV RNA synthesis.
format	article
author	Wei Xu Priya Luthra Chao Wu Jyoti Batra Daisy W. Leung Christopher F. Basler Gaya K. Amarasinghe
author_facet	Wei Xu Priya Luthra Chao Wu Jyoti Batra Daisy W. Leung Christopher F. Basler Gaya K. Amarasinghe
author_sort	Wei Xu
title	Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
title_short	Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
title_full	Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
title_fullStr	Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
title_full_unstemmed	Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis
title_sort	ebola virus vp30 and nucleoprotein interactions modulate viral rna synthesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5c4091a760484f9a90a55306fceabb20
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_version_	1718386290081136640

Ebola virus VP30 and nucleoprotein interactions modulate viral RNA synthesis

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