Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s dis...

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Autores principales:	Dominique Padovani, Assia Hessani, Francine T. Castillo, Géraldine Liot, Mireille Andriamihaja, Annaïg Lan, Camilla Pilati, François Blachier, Suvajit Sen, Erwan Galardon, Isabelle Artaud
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c40bd245f7547b1967ae36a14dcbecc
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spelling	oai:doaj.org-article:5c40bd245f7547b1967ae36a14dcbecc2021-12-02T17:31:34ZSulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases10.1038/ncomms133862041-1723https://doaj.org/article/5c40bd245f7547b1967ae36a14dcbecc2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13386https://doaj.org/toc/2041-1723High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s disease.Dominique PadovaniAssia HessaniFrancine T. CastilloGéraldine LiotMireille AndriamihajaAnnaïg LanCamilla PilatiFrançois BlachierSuvajit SenErwan GalardonIsabelle ArtaudNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dominique Padovani Assia Hessani Francine T. Castillo Géraldine Liot Mireille Andriamihaja Annaïg Lan Camilla Pilati François Blachier Suvajit Sen Erwan Galardon Isabelle Artaud Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
description	High levels of homocysteine in cells are linked to pathological states. Here, the authors report that homocysteine inactivates catalase by modifying the heme group, impairing cellular redox homeostasis, and show that this modification occurs in cancer cells and in a cellular model of Parkinson’s disease.
format	article
author	Dominique Padovani Assia Hessani Francine T. Castillo Géraldine Liot Mireille Andriamihaja Annaïg Lan Camilla Pilati François Blachier Suvajit Sen Erwan Galardon Isabelle Artaud
author_facet	Dominique Padovani Assia Hessani Francine T. Castillo Géraldine Liot Mireille Andriamihaja Annaïg Lan Camilla Pilati François Blachier Suvajit Sen Erwan Galardon Isabelle Artaud
author_sort	Dominique Padovani
title	Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
title_short	Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
title_full	Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
title_fullStr	Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
title_full_unstemmed	Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases
title_sort	sulfheme formation during homocysteine s-oxygenation by catalase in cancers and neurodegenerative diseases
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/5c40bd245f7547b1967ae36a14dcbecc
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Sulfheme formation during homocysteine S-oxygenation by catalase in cancers and neurodegenerative diseases

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