Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

Abstract Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer’s disease (AD). Current AD treatments a...

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Autores principales:	Laura Bonfili, Valentina Cecarini, Sara Berardi, Silvia Scarpona, Jan S. Suchodolski, Cinzia Nasuti, Dennis Fiorini, Maria Chiara Boarelli, Giacomo Rossi, Anna Maria Eleuteri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c43f4eb347f46d58ef7a5f70dd9776e
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spelling	oai:doaj.org-article:5c43f4eb347f46d58ef7a5f70dd9776e2021-12-02T16:06:20ZMicrobiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels10.1038/s41598-017-02587-22045-2322https://doaj.org/article/5c43f4eb347f46d58ef7a5f70dd9776e2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02587-2https://doaj.org/toc/2045-2322Abstract Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer’s disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasma concentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates. Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer’s disease.Laura BonfiliValentina CecariniSara BerardiSilvia ScarponaJan S. SuchodolskiCinzia NasutiDennis FioriniMaria Chiara BoarelliGiacomo RossiAnna Maria EleuteriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-21 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Bonfili Valentina Cecarini Sara Berardi Silvia Scarpona Jan S. Suchodolski Cinzia Nasuti Dennis Fiorini Maria Chiara Boarelli Giacomo Rossi Anna Maria Eleuteri Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
description	Abstract Gut microbiota has a proven role in regulating multiple neuro-chemical pathways through the highly interconnected gut-brain axis. Oral bacteriotherapy thus has potential in the treatment of central nervous system-related pathologies, such as Alzheimer’s disease (AD). Current AD treatments aim to prevent onset, delay progression and ameliorate symptoms. In this work, 3xTg-AD mice in the early stage of AD were treated with SLAB51 probiotic formulation, thereby affecting the composition of gut microbiota and its metabolites. This influenced plasma concentration of inflammatory cytokines and key metabolic hormones considered therapeutic targets in neurodegeneration. Treated mice showed partial restoration of two impaired neuronal proteolytic pathways (the ubiquitin proteasome system and autophagy). Their cognitive decline was decreased compared with controls, due to a reduction in brain damage and reduced accumulation of amyloid beta aggregates. Collectively, our results clearly prove that modulation of the microbiota induces positive effects on neuronal pathways that are able to slow down the progression of Alzheimer’s disease.
format	article
author	Laura Bonfili Valentina Cecarini Sara Berardi Silvia Scarpona Jan S. Suchodolski Cinzia Nasuti Dennis Fiorini Maria Chiara Boarelli Giacomo Rossi Anna Maria Eleuteri
author_facet	Laura Bonfili Valentina Cecarini Sara Berardi Silvia Scarpona Jan S. Suchodolski Cinzia Nasuti Dennis Fiorini Maria Chiara Boarelli Giacomo Rossi Anna Maria Eleuteri
author_sort	Laura Bonfili
title	Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
title_short	Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
title_full	Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
title_fullStr	Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
title_full_unstemmed	Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
title_sort	microbiota modulation counteracts alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5c43f4eb347f46d58ef7a5f70dd9776e
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Microbiota modulation counteracts Alzheimer’s disease progression influencing neuronal proteolysis and gut hormones plasma levels

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