An alternative pathway for membrane protein biogenesis at the endoplasmic reticulum
O’Keefe et al. investigate the integration of type III single-pass transmembrane proteins targeted to the ER and examine the roles of the ER membrane complex, Sec61 complex and signal recognition particle receptor. As a result, the authors propose an alternative mechanism of insertion, reconciling t...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/5c449021283a45d288dc2d9c2bd63056 |
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| Sumario: | O’Keefe et al. investigate the integration of type III single-pass transmembrane proteins targeted to the ER and examine the roles of the ER membrane complex, Sec61 complex and signal recognition particle receptor. As a result, the authors propose an alternative mechanism of insertion, reconciling the ability of type III transmembrane proteins to bypass an ipomoeassin-F-mediated blockade of membrane integration. |
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