High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study

Abstract Background To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up. Methods A total of 4039 participants aged 45 years or above from the China Health and Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) an...

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Autores principales:	Zhiyuan Wu, Haiping Zhang, Xinlei Miao, Haibin Li, Huiying Pan, Di Zhou, Yue Liu, Zhiwei Li, Jinqi Wang, Xiangtong Liu, Deqiang Zheng, Xia Li, Wei Wang, Xiuhua Guo, Lixin Tao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Cognition Physical activity intensity Cohort study Mixed effect model Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5c471b74ef7d4cdc8993a153bf76631c
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spelling	oai:doaj.org-article:5c471b74ef7d4cdc8993a153bf76631c2021-11-08T11:15:36ZHigh-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study10.1186/s13195-021-00923-31758-9193https://doaj.org/article/5c471b74ef7d4cdc8993a153bf76631c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13195-021-00923-3https://doaj.org/toc/1758-9193Abstract Background To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up. Methods A total of 4039 participants aged 45 years or above from the China Health and Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) and followed for cognitive function in visit 2 (2013–2014), visit 3 (2015–2016), and visit 4 (2017–2018). We analyzed the association of PA intensity with global cognition, episodic memory, and mental intactness at baseline using adjusted regression methods and evaluated the long-term effect of PA intensity using multiple measures of cognition scores by mixed effect model. Results In cross-sectional analysis, mild and moderate PA, rather than vigorous PA, was associated with better cognitive performance. The results remained consistent in multiple sensitivity analyses. During the follow-up, participant with mild PA had a 0.56 (95% CI 0.12–0.99) higher global cognition, 0.23 (95% CI 0.01–0.46) higher episodic memory, and 0.33 (95% CI 0.01–0.64) higher mental intactness, while those with moderate PA had a 0.74 (95% CI 0.32–1.17) higher global score, 0.32 (95% CI 0.09–0.54) higher episodic memory, and 0.43 (95% CI 0.12–0.74) higher mental intactness, compared with individuals without PA. Vigorous PA was not beneficial to the long-term cognitive performance. Conclusions Our study indicates that mild and moderate PA could improve cognitive performance, rather than the vigorous activity. The targeted intensity of PA might be more effective to achieve the greatest cognition improvement considering age and depressive status.Zhiyuan WuHaiping ZhangXinlei MiaoHaibin LiHuiying PanDi ZhouYue LiuZhiwei LiJinqi WangXiangtong LiuDeqiang ZhengXia LiWei WangXiuhua GuoLixin TaoBMCarticleCognitionPhysical activity intensityCohort studyMixed effect modelNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAlzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cognition Physical activity intensity Cohort study Mixed effect model Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Cognition Physical activity intensity Cohort study Mixed effect model Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhiyuan Wu Haiping Zhang Xinlei Miao Haibin Li Huiying Pan Di Zhou Yue Liu Zhiwei Li Jinqi Wang Xiangtong Liu Deqiang Zheng Xia Li Wei Wang Xiuhua Guo Lixin Tao High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
description	Abstract Background To evaluate the association of physical activity (PA) intensity with cognitive performance at baseline and during follow-up. Methods A total of 4039 participants aged 45 years or above from the China Health and Retirement Longitudinal Study were enrolled in visit 1 (2011–2012) and followed for cognitive function in visit 2 (2013–2014), visit 3 (2015–2016), and visit 4 (2017–2018). We analyzed the association of PA intensity with global cognition, episodic memory, and mental intactness at baseline using adjusted regression methods and evaluated the long-term effect of PA intensity using multiple measures of cognition scores by mixed effect model. Results In cross-sectional analysis, mild and moderate PA, rather than vigorous PA, was associated with better cognitive performance. The results remained consistent in multiple sensitivity analyses. During the follow-up, participant with mild PA had a 0.56 (95% CI 0.12–0.99) higher global cognition, 0.23 (95% CI 0.01–0.46) higher episodic memory, and 0.33 (95% CI 0.01–0.64) higher mental intactness, while those with moderate PA had a 0.74 (95% CI 0.32–1.17) higher global score, 0.32 (95% CI 0.09–0.54) higher episodic memory, and 0.43 (95% CI 0.12–0.74) higher mental intactness, compared with individuals without PA. Vigorous PA was not beneficial to the long-term cognitive performance. Conclusions Our study indicates that mild and moderate PA could improve cognitive performance, rather than the vigorous activity. The targeted intensity of PA might be more effective to achieve the greatest cognition improvement considering age and depressive status.
format	article
author	Zhiyuan Wu Haiping Zhang Xinlei Miao Haibin Li Huiying Pan Di Zhou Yue Liu Zhiwei Li Jinqi Wang Xiangtong Liu Deqiang Zheng Xia Li Wei Wang Xiuhua Guo Lixin Tao
author_facet	Zhiyuan Wu Haiping Zhang Xinlei Miao Haibin Li Huiying Pan Di Zhou Yue Liu Zhiwei Li Jinqi Wang Xiangtong Liu Deqiang Zheng Xia Li Wei Wang Xiuhua Guo Lixin Tao
author_sort	Zhiyuan Wu
title	High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
title_short	High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
title_full	High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
title_fullStr	High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
title_full_unstemmed	High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study
title_sort	high-intensity physical activity is not associated with better cognition in the elder: evidence from the china health and retirement longitudinal study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5c471b74ef7d4cdc8993a153bf76631c
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High-intensity physical activity is not associated with better cognition in the elder: evidence from the China Health and Retirement Longitudinal Study

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