Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

The Wnt pathway regulates anti-tumour immunity in melanoma. Here, the authors show that, in lung adenocarcinoma, secretion of the ligand Wnt1 induces immune resistance by impairing the ability of dendritic cells to cross-prime T cells, and that blocking Wnt signalling enhances rejection of tumours b...

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Autores principales:	Dimitra Kerdidani, Panagiotis Chouvardas, Ares Rocanin Arjo, Ioanna Giopanou, Giannoula Ntaliarda, Yu Amanda Guo, Mary Tsikitis, Georgios Kazamias, Konstantinos Potaris, Georgios T. Stathopoulos, Spyros Zakynthinos, Ioannis Kalomenidis, Vassili Soumelis, George Kollias, Maria Tsoumakidou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c4ba3c2ceae477a9fdbf372ed7b0ecd
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spelling	oai:doaj.org-article:5c4ba3c2ceae477a9fdbf372ed7b0ecd2021-12-02T14:38:45ZWnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma10.1038/s41467-019-09370-z2041-1723https://doaj.org/article/5c4ba3c2ceae477a9fdbf372ed7b0ecd2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09370-zhttps://doaj.org/toc/2041-1723The Wnt pathway regulates anti-tumour immunity in melanoma. Here, the authors show that, in lung adenocarcinoma, secretion of the ligand Wnt1 induces immune resistance by impairing the ability of dendritic cells to cross-prime T cells, and that blocking Wnt signalling enhances rejection of tumours by acting both on the cancer and immune cells.Dimitra KerdidaniPanagiotis ChouvardasAres Rocanin ArjoIoanna GiopanouGiannoula NtaliardaYu Amanda GuoMary TsikitisGeorgios KazamiasKonstantinos PotarisGeorgios T. StathopoulosSpyros ZakynthinosIoannis KalomenidisVassili SoumelisGeorge KolliasMaria TsoumakidouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dimitra Kerdidani Panagiotis Chouvardas Ares Rocanin Arjo Ioanna Giopanou Giannoula Ntaliarda Yu Amanda Guo Mary Tsikitis Georgios Kazamias Konstantinos Potaris Georgios T. Stathopoulos Spyros Zakynthinos Ioannis Kalomenidis Vassili Soumelis George Kollias Maria Tsoumakidou Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
description	The Wnt pathway regulates anti-tumour immunity in melanoma. Here, the authors show that, in lung adenocarcinoma, secretion of the ligand Wnt1 induces immune resistance by impairing the ability of dendritic cells to cross-prime T cells, and that blocking Wnt signalling enhances rejection of tumours by acting both on the cancer and immune cells.
format	article
author	Dimitra Kerdidani Panagiotis Chouvardas Ares Rocanin Arjo Ioanna Giopanou Giannoula Ntaliarda Yu Amanda Guo Mary Tsikitis Georgios Kazamias Konstantinos Potaris Georgios T. Stathopoulos Spyros Zakynthinos Ioannis Kalomenidis Vassili Soumelis George Kollias Maria Tsoumakidou
author_facet	Dimitra Kerdidani Panagiotis Chouvardas Ares Rocanin Arjo Ioanna Giopanou Giannoula Ntaliarda Yu Amanda Guo Mary Tsikitis Georgios Kazamias Konstantinos Potaris Georgios T. Stathopoulos Spyros Zakynthinos Ioannis Kalomenidis Vassili Soumelis George Kollias Maria Tsoumakidou
author_sort	Dimitra Kerdidani
title	Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
title_short	Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
title_full	Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
title_fullStr	Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
title_full_unstemmed	Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
title_sort	wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/5c4ba3c2ceae477a9fdbf372ed7b0ecd
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Wnt1 silences chemokine genes in dendritic cells and induces adaptive immune resistance in lung adenocarcinoma

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