Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer

Introduction: Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (I...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mona Abdel-Hamed Yehia, Sabah Ali AL-Qadasi, Amel Sobhey AL-Sedfy
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2021
Materias:	her2/neu gp88 clinical pathological parameter invasive ductal carcinoma immunohistochemical staining integrated optical density Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c4f9560f10441b3b12802d30dac59d2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c4f9560f10441b3b12802d30dac59d2
record_format	dspace
spelling	oai:doaj.org-article:5c4f9560f10441b3b12802d30dac59d22021-12-02T15:37:21ZQuantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer10.5281/zenodo.44220742695-5075https://doaj.org/article/5c4f9560f10441b3b12802d30dac59d22021-01-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4422074https://doaj.org/toc/2695-5075Introduction: Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues, as well as its correlation with different pathological parameters. Methods: The immunohistochemical avidin-biotin complex protocol of the paraffin section was used to detect the expression of GP88 and HER2/neu in IDC of 60 patients, 30 benign, and ten normal breast tissues. Results: The study showed a high expression of GP88 in IDC comparing to normal and benign breast tissues. A higher significant statistical correlation between the expression of GP88 and large tumor size, tumor grade, and lymph node metastasis (LNM). While a negative statistical correlation was noticed between the expression of GP88 and ER, PR, and HER2/neu status. Discussion: The results of the quantitative immunostaining density of GP88 glycoprotein antibody revealed it to be a valuable predictive and therapeutic marker of GP88 in human IDC patients.Mona Abdel-Hamed YehiaSabah Ali AL-QadasiAmel Sobhey AL-SedfyEmergency Department of Hospital San Pedro (Logroño, Spain)articleher2/neugp88clinical pathological parameterinvasive ductal carcinomaimmunohistochemical stainingintegrated optical densityMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 1, Pp 33-43 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	her2/neu gp88 clinical pathological parameter invasive ductal carcinoma immunohistochemical staining integrated optical density Medicine (General) R5-920
spellingShingle	her2/neu gp88 clinical pathological parameter invasive ductal carcinoma immunohistochemical staining integrated optical density Medicine (General) R5-920 Mona Abdel-Hamed Yehia Sabah Ali AL-Qadasi Amel Sobhey AL-Sedfy Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
description	Introduction: Progranulin or acrogranin is an 88-kDa glycoprotein identified by a biological screen for protein targets associated with high tumorigenicity. This work was aimed to investigate the digital expression of GP88, and HER2/neu as a predictive biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues, as well as its correlation with different pathological parameters. Methods: The immunohistochemical avidin-biotin complex protocol of the paraffin section was used to detect the expression of GP88 and HER2/neu in IDC of 60 patients, 30 benign, and ten normal breast tissues. Results: The study showed a high expression of GP88 in IDC comparing to normal and benign breast tissues. A higher significant statistical correlation between the expression of GP88 and large tumor size, tumor grade, and lymph node metastasis (LNM). While a negative statistical correlation was noticed between the expression of GP88 and ER, PR, and HER2/neu status. Discussion: The results of the quantitative immunostaining density of GP88 glycoprotein antibody revealed it to be a valuable predictive and therapeutic marker of GP88 in human IDC patients.
format	article
author	Mona Abdel-Hamed Yehia Sabah Ali AL-Qadasi Amel Sobhey AL-Sedfy
author_facet	Mona Abdel-Hamed Yehia Sabah Ali AL-Qadasi Amel Sobhey AL-Sedfy
author_sort	Mona Abdel-Hamed Yehia
title	Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
title_short	Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
title_full	Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
title_fullStr	Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
title_full_unstemmed	Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer
title_sort	quantitative immunohistochemical expression of gp88 in invasive ductal carcinoma (idc) of human breast cancer
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2021
url	https://doaj.org/article/5c4f9560f10441b3b12802d30dac59d2
work_keys_str_mv	AT monaabdelhamedyehia quantitativeimmunohistochemicalexpressionofgp88ininvasiveductalcarcinomaidcofhumanbreastcancer AT sabahalialqadasi quantitativeimmunohistochemicalexpressionofgp88ininvasiveductalcarcinomaidcofhumanbreastcancer AT amelsobheyalsedfy quantitativeimmunohistochemicalexpressionofgp88ininvasiveductalcarcinomaidcofhumanbreastcancer
_version_	1718386174412718080

Quantitative immunohistochemical expression of GP88 in invasive ductal carcinoma (IDC) of human breast cancer

Ejemplares similares