Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering

Muhammad Qasim,1 Dong Sik Chae,2 Nae Yoon Lee11Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea; 2Department of Orthopedic Surgery, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic o...

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Autores principales:	Qasim M, Chae DS, Lee NY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Extracellular matrix 3D 4D Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c54772dbcb540ae9020d2af058078ce
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spelling	oai:doaj.org-article:5c54772dbcb540ae9020d2af058078ce2021-12-02T08:53:10ZAdvancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering1178-2013https://doaj.org/article/5c54772dbcb540ae9020d2af058078ce2019-06-01T00:00:00Zhttps://www.dovepress.com/advancements-and-frontiers-in-nano-based-3d-and-4d-scaffolds-for-bone--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Muhammad Qasim,1 Dong Sik Chae,2 Nae Yoon Lee11Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea; 2Department of Orthopedic Surgery, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of KoreaAbstract: Given the enormous increase in the risks of bone and cartilage defects with the rise in the aging population, the current treatments available are insufficient for handling this burden, and the supply of donor organs for transplantation is limited. Therefore, tissue engineering is a promising approach for treating such defects. Advances in materials research and high-tech optimized fabrication of scaffolds have increased the efficiency of tissue engineering. Electrospun nanofibrous scaffolds and hydrogel scaffolds mimic the native extracellular matrix of bone, providing a support for bone and cartilage tissue engineering by increasing cell viability, adhesion, propagation, and homing, and osteogenic isolation and differentiation, vascularization, host integration, and load bearing. The use of these scaffolds with advanced three- and four-dimensional printing technologies has enabled customized bone grafting. In this review, we discuss the different approaches used for cartilage and bone tissue engineering.Keywords: tissue engineering, extracellular matrix, bioprinting, biomaterialsQasim MChae DSLee NYDove Medical PressarticleExtracellular matrix3D4DMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4333-4351 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extracellular matrix 3D 4D Medicine (General) R5-920
spellingShingle	Extracellular matrix 3D 4D Medicine (General) R5-920 Qasim M Chae DS Lee NY Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
description	Muhammad Qasim,1 Dong Sik Chae,2 Nae Yoon Lee11Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea; 2Department of Orthopedic Surgery, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Republic of KoreaAbstract: Given the enormous increase in the risks of bone and cartilage defects with the rise in the aging population, the current treatments available are insufficient for handling this burden, and the supply of donor organs for transplantation is limited. Therefore, tissue engineering is a promising approach for treating such defects. Advances in materials research and high-tech optimized fabrication of scaffolds have increased the efficiency of tissue engineering. Electrospun nanofibrous scaffolds and hydrogel scaffolds mimic the native extracellular matrix of bone, providing a support for bone and cartilage tissue engineering by increasing cell viability, adhesion, propagation, and homing, and osteogenic isolation and differentiation, vascularization, host integration, and load bearing. The use of these scaffolds with advanced three- and four-dimensional printing technologies has enabled customized bone grafting. In this review, we discuss the different approaches used for cartilage and bone tissue engineering.Keywords: tissue engineering, extracellular matrix, bioprinting, biomaterials
format	article
author	Qasim M Chae DS Lee NY
author_facet	Qasim M Chae DS Lee NY
author_sort	Qasim M
title	Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
title_short	Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
title_full	Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
title_fullStr	Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
title_full_unstemmed	Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering
title_sort	advancements and frontiers in nano-based 3d and 4d scaffolds for bone and cartilage tissue engineering
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/5c54772dbcb540ae9020d2af058078ce
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Advancements and frontiers in nano-based 3D and 4D scaffolds for bone and cartilage tissue engineering

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