Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.

During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple cancer types, characterized by a gene expression signature with prominent presence...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaiyi Zhu, Lingyi Cai, Chenqian Cui, Juan R de Los Toyos, Dimitris Anastassiou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5c5566e401cb4860abc940ba5c8ea226
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c5566e401cb4860abc940ba5c8ea226
record_format	dspace
spelling	oai:doaj.org-article:5c5566e401cb4860abc940ba5c8ea2262021-12-02T19:57:23ZSingle-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.1553-734X1553-735810.1371/journal.pcbi.1009228https://doaj.org/article/5c5566e401cb4860abc940ba5c8ea2262021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009228https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple cancer types, characterized by a gene expression signature with prominent presence of genes COL11A1, THBS2 and INHBA. Identifying the underlying biological mechanisms responsible for their creation may facilitate the discovery of targets for potential pan-cancer therapeutics. Using a novel computational approach for single-cell gene expression data analysis identifying the dominant cell populations in a sequence of samples from patients at various stages, we conclude that these fibroblasts are produced by a pan-cancer cellular transition originating from a particular type of adipose-derived stromal cells naturally present in the stromal vascular fraction of normal adipose tissue, having a characteristic gene expression signature. Focusing on a rich pancreatic cancer dataset, we provide a detailed description of the continuous modification of the gene expression profiles of cells as they transition from APOD-expressing adipose-derived stromal cells to COL11A1-expressing cancer-associated fibroblasts, identifying the key genes that participate in this transition. These results also provide an explanation to the well-known fact that the adipose microenvironment contributes to cancer progression.Kaiyi ZhuLingyi CaiChenqian CuiJuan R de Los ToyosDimitris AnastassiouPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 7, p e1009228 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Kaiyi Zhu Lingyi Cai Chenqian Cui Juan R de Los Toyos Dimitris Anastassiou Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
description	During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple cancer types, characterized by a gene expression signature with prominent presence of genes COL11A1, THBS2 and INHBA. Identifying the underlying biological mechanisms responsible for their creation may facilitate the discovery of targets for potential pan-cancer therapeutics. Using a novel computational approach for single-cell gene expression data analysis identifying the dominant cell populations in a sequence of samples from patients at various stages, we conclude that these fibroblasts are produced by a pan-cancer cellular transition originating from a particular type of adipose-derived stromal cells naturally present in the stromal vascular fraction of normal adipose tissue, having a characteristic gene expression signature. Focusing on a rich pancreatic cancer dataset, we provide a detailed description of the continuous modification of the gene expression profiles of cells as they transition from APOD-expressing adipose-derived stromal cells to COL11A1-expressing cancer-associated fibroblasts, identifying the key genes that participate in this transition. These results also provide an explanation to the well-known fact that the adipose microenvironment contributes to cancer progression.
format	article
author	Kaiyi Zhu Lingyi Cai Chenqian Cui Juan R de Los Toyos Dimitris Anastassiou
author_facet	Kaiyi Zhu Lingyi Cai Chenqian Cui Juan R de Los Toyos Dimitris Anastassiou
author_sort	Kaiyi Zhu
title	Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
title_short	Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
title_full	Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
title_fullStr	Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
title_full_unstemmed	Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.
title_sort	single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into col11a1-expressing cancer-associated fibroblasts.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5c5566e401cb4860abc940ba5c8ea226
work_keys_str_mv	AT kaiyizhu singlecellanalysisrevealsthepancancerinvasivenessassociatedtransitionofadiposederivedstromalcellsintocol11a1expressingcancerassociatedfibroblasts AT lingyicai singlecellanalysisrevealsthepancancerinvasivenessassociatedtransitionofadiposederivedstromalcellsintocol11a1expressingcancerassociatedfibroblasts AT chenqiancui singlecellanalysisrevealsthepancancerinvasivenessassociatedtransitionofadiposederivedstromalcellsintocol11a1expressingcancerassociatedfibroblasts AT juanrdelostoyos singlecellanalysisrevealsthepancancerinvasivenessassociatedtransitionofadiposederivedstromalcellsintocol11a1expressingcancerassociatedfibroblasts AT dimitrisanastassiou singlecellanalysisrevealsthepancancerinvasivenessassociatedtransitionofadiposederivedstromalcellsintocol11a1expressingcancerassociatedfibroblasts
_version_	1718375841126154240

Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.

Ejemplares similares