Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

Vaccination with BCGΔBCG1419c protects against pulmonary and extrapulmonary TB and is safer than BCG

Abstract A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c was more atte...

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Autores principales: Michel de Jesús Aceves-Sánchez, Mario Alberto Flores-Valdez, César Pedroza-Roldán, Elizabeth Creissen, Linda Izzo, Fabiola Silva-Angulo, Clinton Dawson, Angelo Izzo, Helle Bielefeldt-Ohmann, Cristian Alfredo Segura-Cerda, Wendy López-Romero, Jorge Bravo-Madrigal, Jorge Alberto Barrios-Payán, Miguel Ángel de la Cruz, Miguel Ares, María Guadalupe Jorge-Espinoza
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/5c59aca1dc2a4630bd0accb20d8195d8
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