Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers

Kenji Inoue1, Kei Noguchi1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively evaluate the diurnal variation of intraocular pressure (IOP) during unoprostone treatment in 13 healthy v...

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Autores principales:	Inoue K, Noguchi K, Wakakura M, Tomita G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/5c5c4354a940463ca91f598d1b299bcf
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spelling	oai:doaj.org-article:5c5c4354a940463ca91f598d1b299bcf2021-12-02T05:12:21ZEffects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers1177-54671177-5483https://doaj.org/article/5c5c4354a940463ca91f598d1b299bcf2011-07-01T00:00:00Zhttp://www.dovepress.com/effects-of-unoprostone-on-diurnal-variation-of-intraocular-pressure-in-a7880https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kenji Inoue1, Kei Noguchi1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively evaluate the diurnal variation of intraocular pressure (IOP) during unoprostone treatment in 13 healthy volunteers.Method: IOP was measured by Goldmann applanation tonometry by the same observer every 3 hours from 9 am to 9 am the next morning. Unoprostone was then instilled at 9 am and 9 pm daily for 1 month. After 1 month, IOP was measured again with unoprostone instilled at 9 am and 9 pm during IOP measurement. We then compared the average daily IOP before and after the treatment (paired t-test).Results: After 1 month of treatment, the average IOP decreased at every time point but one (12 pm, 3 pm, 6 pm, 9 pm, 12 am, 3 am, and 9 am, but not at 6 am). There were no adverse reactions and none of the subjects discontinued unoprostone.Conclusion: The hypotensive effects of unoprostone persist throughout the day, but this study suggests that the effects may be weaker at nighttime and early in the morning.Keywords: unoprostone, intraocular pressure, diurnal variation, healthy volunteerInoue KNoguchi KWakakura MTomita GDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1003-1005 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Inoue K Noguchi K Wakakura M Tomita G Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
description	Kenji Inoue1, Kei Noguchi1, Masato Wakakura1, Goji Tomita21Inouye Eye Hospital, Tokyo; 22nd Department of Ophthalmology, Toho University School of Medicine, Tokyo, JapanPurpose: To prospectively evaluate the diurnal variation of intraocular pressure (IOP) during unoprostone treatment in 13 healthy volunteers.Method: IOP was measured by Goldmann applanation tonometry by the same observer every 3 hours from 9 am to 9 am the next morning. Unoprostone was then instilled at 9 am and 9 pm daily for 1 month. After 1 month, IOP was measured again with unoprostone instilled at 9 am and 9 pm during IOP measurement. We then compared the average daily IOP before and after the treatment (paired t-test).Results: After 1 month of treatment, the average IOP decreased at every time point but one (12 pm, 3 pm, 6 pm, 9 pm, 12 am, 3 am, and 9 am, but not at 6 am). There were no adverse reactions and none of the subjects discontinued unoprostone.Conclusion: The hypotensive effects of unoprostone persist throughout the day, but this study suggests that the effects may be weaker at nighttime and early in the morning.Keywords: unoprostone, intraocular pressure, diurnal variation, healthy volunteer
format	article
author	Inoue K Noguchi K Wakakura M Tomita G
author_facet	Inoue K Noguchi K Wakakura M Tomita G
author_sort	Inoue K
title	Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
title_short	Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
title_full	Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
title_fullStr	Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
title_full_unstemmed	Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
title_sort	effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/5c5c4354a940463ca91f598d1b299bcf
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Effects of unoprostone on diurnal variation of intraocular pressure in healthy volunteers

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