Immuno-enhancing effects of fruit of Actinidia polygama in macrophages

In this study, we evaluated the functionality of water extracts from the fruit of Actinidia polygama (APF) in macrophages. The APF is a medicinal plant belonging to Actinidiaceae, it has been reported to exert anti-inflammatory, analgesic and hypouricemic activities. However, the potential mechanism...

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Autores principales:	Hyun Ji Eo, Hanna Shin, Jeong Ho Song, Gwang Hun Park
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	actinidia polygama immunomodulatory activity macrophages mapk nf-κb Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5c5f6619d7a742a9a0734c53ff13f7f6
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spelling	oai:doaj.org-article:5c5f6619d7a742a9a0734c53ff13f7f62021-11-04T15:00:41ZImmuno-enhancing effects of fruit of Actinidia polygama in macrophages0954-01051465-344310.1080/09540105.2021.1982868https://doaj.org/article/5c5f6619d7a742a9a0734c53ff13f7f62021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2021.1982868https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443In this study, we evaluated the functionality of water extracts from the fruit of Actinidia polygama (APF) in macrophages. The APF is a medicinal plant belonging to Actinidiaceae, it has been reported to exert anti-inflammatory, analgesic and hypouricemic activities. However, the potential mechanism for the immune activation of the APF is still insufficient. So, we evaluated whether APF exerts immune activation activities and elucidated its potential mechanism in macrophages. The APF dose-dependently increased the production of immunomodulators in macrophages. The inhibition of Toll-like receptor 4 (TLR4) blocked APF-mediated production of immunomodulators in RAW264.7 cells. In addition, APF-mediated production of immunomodulators was attenuated by MAPKs and NF-κB inhibition in RAW264.7 cells. Also, we analyzed the sugars content of the APF. The contents of glucose, galactose and fructose were 3597, 904, 7582 mg/L, respectively. These results suggest that the APF may have great potential for the development of immunomodulatory drugs.Hyun Ji EoHanna ShinJeong Ho SongGwang Hun ParkTaylor & Francis Grouparticleactinidia polygamaimmunomodulatory activitymacrophagesmapknf-κbAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 32, Iss 1, Pp 754-765 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	actinidia polygama immunomodulatory activity macrophages mapk nf-κb Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	actinidia polygama immunomodulatory activity macrophages mapk nf-κb Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Hyun Ji Eo Hanna Shin Jeong Ho Song Gwang Hun Park Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
description	In this study, we evaluated the functionality of water extracts from the fruit of Actinidia polygama (APF) in macrophages. The APF is a medicinal plant belonging to Actinidiaceae, it has been reported to exert anti-inflammatory, analgesic and hypouricemic activities. However, the potential mechanism for the immune activation of the APF is still insufficient. So, we evaluated whether APF exerts immune activation activities and elucidated its potential mechanism in macrophages. The APF dose-dependently increased the production of immunomodulators in macrophages. The inhibition of Toll-like receptor 4 (TLR4) blocked APF-mediated production of immunomodulators in RAW264.7 cells. In addition, APF-mediated production of immunomodulators was attenuated by MAPKs and NF-κB inhibition in RAW264.7 cells. Also, we analyzed the sugars content of the APF. The contents of glucose, galactose and fructose were 3597, 904, 7582 mg/L, respectively. These results suggest that the APF may have great potential for the development of immunomodulatory drugs.
format	article
author	Hyun Ji Eo Hanna Shin Jeong Ho Song Gwang Hun Park
author_facet	Hyun Ji Eo Hanna Shin Jeong Ho Song Gwang Hun Park
author_sort	Hyun Ji Eo
title	Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
title_short	Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
title_full	Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
title_fullStr	Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
title_full_unstemmed	Immuno-enhancing effects of fruit of Actinidia polygama in macrophages
title_sort	immuno-enhancing effects of fruit of actinidia polygama in macrophages
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/5c5f6619d7a742a9a0734c53ff13f7f6
work_keys_str_mv	AT hyunjieo immunoenhancingeffectsoffruitofactinidiapolygamainmacrophages AT hannashin immunoenhancingeffectsoffruitofactinidiapolygamainmacrophages AT jeonghosong immunoenhancingeffectsoffruitofactinidiapolygamainmacrophages AT gwanghunpark immunoenhancingeffectsoffruitofactinidiapolygamainmacrophages
_version_	1718444772439359488

Immuno-enhancing effects of fruit of Actinidia polygama in macrophages

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