Natural product-based nanomedicine: recent advances and issues

Natural product-based nanomedicine: recent advances and issues

Rebekah Watkins,1,2,* Ling Wu,1,* Chenming Zhang,3–5 Richey M Davis,3,5,6 Bin Xu1,3 1Department of Biochemistry, 2Program in Nanoscience, 3Center for Drug Discovery, 4Department of Biological Systems Engineering, 5Institute for Critical Technology and Applied Science, 6Department of Chemi...

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Autores principales: Watkins R, Wu L, Zhang C, Davis RM, Xu B
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2015
Materias:
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/5c62cb4071c641d2b6126bdda839d783
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spelling oai:doaj.org-article:5c62cb4071c641d2b6126bdda839d7832021-12-02T02:40:52ZNatural product-based nanomedicine: recent advances and issues1178-2013https://doaj.org/article/5c62cb4071c641d2b6126bdda839d7832015-09-01T00:00:00Zhttps://www.dovepress.com/natural-product-based-nanomedicine-recent-advances-and-issues-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Rebekah Watkins,1,2,* Ling Wu,1,* Chenming Zhang,3–5 Richey M Davis,3,5,6 Bin Xu1,3 1Department of Biochemistry, 2Program in Nanoscience, 3Center for Drug Discovery, 4Department of Biological Systems Engineering, 5Institute for Critical Technology and Applied Science, 6Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA *These authors contributed equally to this work Abstract: Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications. Keywords: natural products, nanomedicine, drug delivery, bioavailability, targeting, controlled releaseWatkins RWu LZhang CDavis RMXu BDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 6055-6074 (2015)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Watkins R
Wu L
Zhang C
Davis RM
Xu B
Natural product-based nanomedicine: recent advances and issues
description Rebekah Watkins,1,2,* Ling Wu,1,* Chenming Zhang,3–5 Richey M Davis,3,5,6 Bin Xu1,3 1Department of Biochemistry, 2Program in Nanoscience, 3Center for Drug Discovery, 4Department of Biological Systems Engineering, 5Institute for Critical Technology and Applied Science, 6Department of Chemical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA *These authors contributed equally to this work Abstract: Natural products have been used in medicine for many years. Many top-selling pharmaceuticals are natural compounds or their derivatives. These plant- or microorganism-derived compounds have shown potential as therapeutic agents against cancer, microbial infection, inflammation, and other disease conditions. However, their success in clinical trials has been less impressive, partly due to the compounds’ low bioavailability. The incorporation of nanoparticles into a delivery system for natural products would be a major advance in the efforts to increase their therapeutic effects. Recently, advances have been made showing that nanoparticles can significantly increase the bioavailability of natural products both in vitro and in vivo. Nanotechnology has demonstrated its capability to manipulate particles in order to target specific areas of the body and control the release of drugs. Although there are many benefits to applying nanotechnology for better delivery of natural products, it is not without issues. Drug targeting remains a challenge and potential nanoparticle toxicity needs to be further investigated, especially if these systems are to be used to treat chronic human diseases. This review aims to summarize recent progress in several key areas relevant to natural products in nanoparticle delivery systems for biomedical applications. Keywords: natural products, nanomedicine, drug delivery, bioavailability, targeting, controlled release
format article
author Watkins R
Wu L
Zhang C
Davis RM
Xu B
author_facet Watkins R
Wu L
Zhang C
Davis RM
Xu B
author_sort Watkins R
title Natural product-based nanomedicine: recent advances and issues
title_short Natural product-based nanomedicine: recent advances and issues
title_full Natural product-based nanomedicine: recent advances and issues
title_fullStr Natural product-based nanomedicine: recent advances and issues
title_full_unstemmed Natural product-based nanomedicine: recent advances and issues
title_sort natural product-based nanomedicine: recent advances and issues
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/5c62cb4071c641d2b6126bdda839d783
work_keys_str_mv AT watkinsr naturalproductbasednanomedicinerecentadvancesandissues
AT wul naturalproductbasednanomedicinerecentadvancesandissues
AT zhangc naturalproductbasednanomedicinerecentadvancesandissues
AT davisrm naturalproductbasednanomedicinerecentadvancesandissues
AT xub naturalproductbasednanomedicinerecentadvancesandissues
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