Estimation of immune cell content in tumour tissue using single-cell RNA-seq data

Mathematical approaches can be used to assess immune cell composition from the tumour's bulk expression data. Here the authors optimise the CYBERSORT-based deconvolution algorithm by including cell type-specific reference gene expression profiles generated from tumour-derived single-cell RNA se...

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Autores principales:	Max Schelker, Sonia Feau, Jinyan Du, Nav Ranu, Edda Klipp, Gavin MacBeath, Birgit Schoeberl, Andreas Raue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c63f788f9dd4251a8c28f805ab97385
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spelling	oai:doaj.org-article:5c63f788f9dd4251a8c28f805ab973852021-12-02T14:40:21ZEstimation of immune cell content in tumour tissue using single-cell RNA-seq data10.1038/s41467-017-02289-32041-1723https://doaj.org/article/5c63f788f9dd4251a8c28f805ab973852017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02289-3https://doaj.org/toc/2041-1723Mathematical approaches can be used to assess immune cell composition from the tumour's bulk expression data. Here the authors optimise the CYBERSORT-based deconvolution algorithm by including cell type-specific reference gene expression profiles generated from tumour-derived single-cell RNA sequencing data.Max SchelkerSonia FeauJinyan DuNav RanuEdda KlippGavin MacBeathBirgit SchoeberlAndreas RaueNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Max Schelker Sonia Feau Jinyan Du Nav Ranu Edda Klipp Gavin MacBeath Birgit Schoeberl Andreas Raue Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
description	Mathematical approaches can be used to assess immune cell composition from the tumour's bulk expression data. Here the authors optimise the CYBERSORT-based deconvolution algorithm by including cell type-specific reference gene expression profiles generated from tumour-derived single-cell RNA sequencing data.
format	article
author	Max Schelker Sonia Feau Jinyan Du Nav Ranu Edda Klipp Gavin MacBeath Birgit Schoeberl Andreas Raue
author_facet	Max Schelker Sonia Feau Jinyan Du Nav Ranu Edda Klipp Gavin MacBeath Birgit Schoeberl Andreas Raue
author_sort	Max Schelker
title	Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
title_short	Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
title_full	Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
title_fullStr	Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
title_full_unstemmed	Estimation of immune cell content in tumour tissue using single-cell RNA-seq data
title_sort	estimation of immune cell content in tumour tissue using single-cell rna-seq data
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5c63f788f9dd4251a8c28f805ab97385
work_keys_str_mv	AT maxschelker estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT soniafeau estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT jinyandu estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT navranu estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT eddaklipp estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT gavinmacbeath estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT birgitschoeberl estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata AT andreasraue estimationofimmunecellcontentintumourtissueusingsinglecellrnaseqdata
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Estimation of immune cell content in tumour tissue using single-cell RNA-seq data

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