Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis

Introduction: Colorectal cancer (CRC) is the second leading cause of cancer related death in the world after lung cancer. Early detection of CRC leads to improvement in cancer survival rate. In recent years, efforts have been made to discover a non-invasive screening marker of higher sensitivity and...

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Autores principales:	Abdul Rahman Ramdzan, Muhammad Aklil Abd Rahim, Aznida Mohamad Zaki, Zuraidah Zaidun, Azmawati Mohammed Nawi
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2019
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/5c65384307744661b08a7d931d81b47b
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spelling	oai:doaj.org-article:5c65384307744661b08a7d931d81b47b2021-12-02T01:47:43ZDiagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis2214-999610.5334/aogh.2466https://doaj.org/article/5c65384307744661b08a7d931d81b47b2019-05-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2466https://doaj.org/toc/2214-9996Introduction: Colorectal cancer (CRC) is the second leading cause of cancer related death in the world after lung cancer. Early detection of CRC leads to improvement in cancer survival rate. In recent years, efforts have been made to discover a non-invasive screening marker of higher sensitivity and specificity. Fecal occult blood testing (FOBT) and genetic testing become alternative modalities to screen CRC in the population other than colonoscopy. The aim of this systematic review and meta-analysis is to determine the diagnostic accuracy, sensitivity and specificity of FOBT and genetic testing as screening tools in colorectal cancer. Methods: A literature search of PubMed, ScienceDirect, and Scopus was carried out. The search strategy was restricted to human subjects and studies are published in English. Data on sensitivity and specificity were extracted and pooled. Heterogeneity was assumed at significance level of p < 0.10 and was tested by chi squared. Degree of heterogeneity was quantified using the I2 statistic, and values of less than 25% is considered as homogenous. All analyses were performed using the software Meta-Disc. Results: A total of eleven studies were suitable for data synthesis and analysis. Five studies were analyzed for the accuracy of genetic testing, the pooled estimate for sensitivity and specificity were 71% (95% CI: 66, 75%) and 95% (95% CI: 93, 97%) respectively. Another group of studies which had been evaluated for the accuracy of FOBT, the pooled sensitivity was 31% (95% CI: 25, 38%) while the pooled specificity was 87% (95% CI: 86, 89%). Conclusions: FOBTs is recommended to use as population-based screening tools for colorectal cancer while genetic testing should be focusing on patients with moderate and high risk individuals.Abdul Rahman RamdzanMuhammad Aklil Abd RahimAznida Mohamad ZakiZuraidah ZaidunAzmawati Mohammed NawiUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 85, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Abdul Rahman Ramdzan Muhammad Aklil Abd Rahim Aznida Mohamad Zaki Zuraidah Zaidun Azmawati Mohammed Nawi Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
description	Introduction: Colorectal cancer (CRC) is the second leading cause of cancer related death in the world after lung cancer. Early detection of CRC leads to improvement in cancer survival rate. In recent years, efforts have been made to discover a non-invasive screening marker of higher sensitivity and specificity. Fecal occult blood testing (FOBT) and genetic testing become alternative modalities to screen CRC in the population other than colonoscopy. The aim of this systematic review and meta-analysis is to determine the diagnostic accuracy, sensitivity and specificity of FOBT and genetic testing as screening tools in colorectal cancer. Methods: A literature search of PubMed, ScienceDirect, and Scopus was carried out. The search strategy was restricted to human subjects and studies are published in English. Data on sensitivity and specificity were extracted and pooled. Heterogeneity was assumed at significance level of p < 0.10 and was tested by chi squared. Degree of heterogeneity was quantified using the I2 statistic, and values of less than 25% is considered as homogenous. All analyses were performed using the software Meta-Disc. Results: A total of eleven studies were suitable for data synthesis and analysis. Five studies were analyzed for the accuracy of genetic testing, the pooled estimate for sensitivity and specificity were 71% (95% CI: 66, 75%) and 95% (95% CI: 93, 97%) respectively. Another group of studies which had been evaluated for the accuracy of FOBT, the pooled sensitivity was 31% (95% CI: 25, 38%) while the pooled specificity was 87% (95% CI: 86, 89%). Conclusions: FOBTs is recommended to use as population-based screening tools for colorectal cancer while genetic testing should be focusing on patients with moderate and high risk individuals.
format	article
author	Abdul Rahman Ramdzan Muhammad Aklil Abd Rahim Aznida Mohamad Zaki Zuraidah Zaidun Azmawati Mohammed Nawi
author_facet	Abdul Rahman Ramdzan Muhammad Aklil Abd Rahim Aznida Mohamad Zaki Zuraidah Zaidun Azmawati Mohammed Nawi
author_sort	Abdul Rahman Ramdzan
title	Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
title_short	Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
title_full	Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
title_fullStr	Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
title_full_unstemmed	Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis
title_sort	diagnostic accuracy of fobt and colorectal cancer genetic testing: a systematic review & meta-analysis
publisher	Ubiquity Press
publishDate	2019
url	https://doaj.org/article/5c65384307744661b08a7d931d81b47b
work_keys_str_mv	AT abdulrahmanramdzan diagnosticaccuracyoffobtandcolorectalcancergenetictestingasystematicreviewmetaanalysis AT muhammadaklilabdrahim diagnosticaccuracyoffobtandcolorectalcancergenetictestingasystematicreviewmetaanalysis AT aznidamohamadzaki diagnosticaccuracyoffobtandcolorectalcancergenetictestingasystematicreviewmetaanalysis AT zuraidahzaidun diagnosticaccuracyoffobtandcolorectalcancergenetictestingasystematicreviewmetaanalysis AT azmawatimohammednawi diagnosticaccuracyoffobtandcolorectalcancergenetictestingasystematicreviewmetaanalysis
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Diagnostic Accuracy of FOBT and Colorectal Cancer Genetic Testing: A Systematic Review & Meta-Analysis

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