Disentangling post-vaccination symptoms from early COVID-19

Background: Identifying and testing individuals likely to have SARS-CoV-2 is critical for infection control, including post-vaccination. Vaccination is a major public health strategy to reduce SARS-CoV-2 infection globally. Some individuals experience systemic symptoms post-vaccination, which overla...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liane S. Canas, PhD, Marc F. Österdahl, MRCP, Jie Deng, PhD, Christina Hu, MA, Somesh Selvachandran, MEng, Lorenzo Polidori, MSc, Anna May, MSc, Erika Molteni, PhD, Benjamin Murray, MSc, Liyuan Chen, MSc, Eric Kerfoot, PhD, Kerstin Klaser, PhD, Michela Antonelli, PhD, Alexander Hammers, PhD, Tim Spector, FRCP PhD, Sebastien Ourselin, PhD, Claire Steves, MRCP PhD, Carole H. Sudre, PhD, Marc Modat, PhD, Emma L. Duncan, FRACP PhD
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	COVID-19 detection Vaccination Side-effects Self-reported symptoms Mobile technology Early detection Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c678cb7585c4ad3b690b7a1a3285287
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c678cb7585c4ad3b690b7a1a3285287
record_format	dspace
spelling	oai:doaj.org-article:5c678cb7585c4ad3b690b7a1a32852872021-12-04T04:35:36ZDisentangling post-vaccination symptoms from early COVID-192589-537010.1016/j.eclinm.2021.101212https://doaj.org/article/5c678cb7585c4ad3b690b7a1a32852872021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589537021004934https://doaj.org/toc/2589-5370Background: Identifying and testing individuals likely to have SARS-CoV-2 is critical for infection control, including post-vaccination. Vaccination is a major public health strategy to reduce SARS-CoV-2 infection globally. Some individuals experience systemic symptoms post-vaccination, which overlap with COVID-19 symptoms. This study compared early post-vaccination symptoms in individuals who subsequently tested positive or negative for SARS-CoV-2, using data from the COVID Symptom Study (CSS) app. Methods: We conducted a prospective observational study in 1,072,313 UK CSS participants who were asymptomatic when vaccinated with Pfizer-BioNTech mRNA vaccine (BNT162b2) or Oxford-AstraZeneca adenovirus-vectored vaccine (ChAdOx1 nCoV-19) between 8 December 2020 and 17 May 2021, who subsequently reported symptoms within seven days (N=362,770) (other than local symptoms at injection site) and were tested for SARS-CoV-2 (N=14,842), aiming to differentiate vaccination side-effects per se from superimposed SARS-CoV-2 infection. The post-vaccination symptoms and SARS-CoV-2 test results were contemporaneously logged by participants. Demographic and clinical information (including comorbidities) were recorded. Symptom profiles in individuals testing positive were compared with a 1:1 matched population testing negative, including using machine learning and multiple models considering UK testing criteria. Findings: Differentiating post-vaccination side-effects alone from early COVID-19 was challenging, with a sensitivity in identification of individuals testing positive of 0.6 at best. Most of these individuals did not have fever, persistent cough, or anosmia/dysosmia, requisite symptoms for accessing UK testing; and many only had systemic symptoms commonly seen post-vaccination in individuals negative for SARS-CoV-2 (headache, myalgia, and fatigue). Interpretation: Post-vaccination symptoms per se cannot be differentiated from COVID-19 with clinical robustness, either using symptom profiles or machine-derived models. Individuals presenting with systemic symptoms post-vaccination should be tested for SARS-CoV-2 or quarantining, to prevent community spread. Funding: UK Government Department of Health and Social Care, Wellcome Trust, UK Engineering and Physical Sciences Research Council, UK National Institute for Health Research, UK Medical Research Council and British Heart Foundation, Chronic Disease Research Foundation, Zoe Limited.Liane S. Canas, PhDMarc F. Österdahl, MRCPJie Deng, PhDChristina Hu, MASomesh Selvachandran, MEngLorenzo Polidori, MScAnna May, MScErika Molteni, PhDBenjamin Murray, MScLiyuan Chen, MScEric Kerfoot, PhDKerstin Klaser, PhDMichela Antonelli, PhDAlexander Hammers, PhDTim Spector, FRCP PhDSebastien Ourselin, PhDClaire Steves, MRCP PhDCarole H. Sudre, PhDMarc Modat, PhDEmma L. Duncan, FRACP PhDElsevierarticleCOVID-19 detectionVaccinationSide-effectsSelf-reported symptomsMobile technologyEarly detectionMedicine (General)R5-920ENEClinicalMedicine, Vol 42, Iss , Pp 101212- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 detection Vaccination Side-effects Self-reported symptoms Mobile technology Early detection Medicine (General) R5-920
spellingShingle	COVID-19 detection Vaccination Side-effects Self-reported symptoms Mobile technology Early detection Medicine (General) R5-920 Liane S. Canas, PhD Marc F. Österdahl, MRCP Jie Deng, PhD Christina Hu, MA Somesh Selvachandran, MEng Lorenzo Polidori, MSc Anna May, MSc Erika Molteni, PhD Benjamin Murray, MSc Liyuan Chen, MSc Eric Kerfoot, PhD Kerstin Klaser, PhD Michela Antonelli, PhD Alexander Hammers, PhD Tim Spector, FRCP PhD Sebastien Ourselin, PhD Claire Steves, MRCP PhD Carole H. Sudre, PhD Marc Modat, PhD Emma L. Duncan, FRACP PhD Disentangling post-vaccination symptoms from early COVID-19
description	Background: Identifying and testing individuals likely to have SARS-CoV-2 is critical for infection control, including post-vaccination. Vaccination is a major public health strategy to reduce SARS-CoV-2 infection globally. Some individuals experience systemic symptoms post-vaccination, which overlap with COVID-19 symptoms. This study compared early post-vaccination symptoms in individuals who subsequently tested positive or negative for SARS-CoV-2, using data from the COVID Symptom Study (CSS) app. Methods: We conducted a prospective observational study in 1,072,313 UK CSS participants who were asymptomatic when vaccinated with Pfizer-BioNTech mRNA vaccine (BNT162b2) or Oxford-AstraZeneca adenovirus-vectored vaccine (ChAdOx1 nCoV-19) between 8 December 2020 and 17 May 2021, who subsequently reported symptoms within seven days (N=362,770) (other than local symptoms at injection site) and were tested for SARS-CoV-2 (N=14,842), aiming to differentiate vaccination side-effects per se from superimposed SARS-CoV-2 infection. The post-vaccination symptoms and SARS-CoV-2 test results were contemporaneously logged by participants. Demographic and clinical information (including comorbidities) were recorded. Symptom profiles in individuals testing positive were compared with a 1:1 matched population testing negative, including using machine learning and multiple models considering UK testing criteria. Findings: Differentiating post-vaccination side-effects alone from early COVID-19 was challenging, with a sensitivity in identification of individuals testing positive of 0.6 at best. Most of these individuals did not have fever, persistent cough, or anosmia/dysosmia, requisite symptoms for accessing UK testing; and many only had systemic symptoms commonly seen post-vaccination in individuals negative for SARS-CoV-2 (headache, myalgia, and fatigue). Interpretation: Post-vaccination symptoms per se cannot be differentiated from COVID-19 with clinical robustness, either using symptom profiles or machine-derived models. Individuals presenting with systemic symptoms post-vaccination should be tested for SARS-CoV-2 or quarantining, to prevent community spread. Funding: UK Government Department of Health and Social Care, Wellcome Trust, UK Engineering and Physical Sciences Research Council, UK National Institute for Health Research, UK Medical Research Council and British Heart Foundation, Chronic Disease Research Foundation, Zoe Limited.
format	article
author	Liane S. Canas, PhD Marc F. Österdahl, MRCP Jie Deng, PhD Christina Hu, MA Somesh Selvachandran, MEng Lorenzo Polidori, MSc Anna May, MSc Erika Molteni, PhD Benjamin Murray, MSc Liyuan Chen, MSc Eric Kerfoot, PhD Kerstin Klaser, PhD Michela Antonelli, PhD Alexander Hammers, PhD Tim Spector, FRCP PhD Sebastien Ourselin, PhD Claire Steves, MRCP PhD Carole H. Sudre, PhD Marc Modat, PhD Emma L. Duncan, FRACP PhD
author_facet	Liane S. Canas, PhD Marc F. Österdahl, MRCP Jie Deng, PhD Christina Hu, MA Somesh Selvachandran, MEng Lorenzo Polidori, MSc Anna May, MSc Erika Molteni, PhD Benjamin Murray, MSc Liyuan Chen, MSc Eric Kerfoot, PhD Kerstin Klaser, PhD Michela Antonelli, PhD Alexander Hammers, PhD Tim Spector, FRCP PhD Sebastien Ourselin, PhD Claire Steves, MRCP PhD Carole H. Sudre, PhD Marc Modat, PhD Emma L. Duncan, FRACP PhD
author_sort	Liane S. Canas, PhD
title	Disentangling post-vaccination symptoms from early COVID-19
title_short	Disentangling post-vaccination symptoms from early COVID-19
title_full	Disentangling post-vaccination symptoms from early COVID-19
title_fullStr	Disentangling post-vaccination symptoms from early COVID-19
title_full_unstemmed	Disentangling post-vaccination symptoms from early COVID-19
title_sort	disentangling post-vaccination symptoms from early covid-19
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/5c678cb7585c4ad3b690b7a1a3285287
work_keys_str_mv	AT lianescanasphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT marcfosterdahlmrcp disentanglingpostvaccinationsymptomsfromearlycovid19 AT jiedengphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT christinahuma disentanglingpostvaccinationsymptomsfromearlycovid19 AT someshselvachandranmeng disentanglingpostvaccinationsymptomsfromearlycovid19 AT lorenzopolidorimsc disentanglingpostvaccinationsymptomsfromearlycovid19 AT annamaymsc disentanglingpostvaccinationsymptomsfromearlycovid19 AT erikamolteniphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT benjaminmurraymsc disentanglingpostvaccinationsymptomsfromearlycovid19 AT liyuanchenmsc disentanglingpostvaccinationsymptomsfromearlycovid19 AT erickerfootphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT kerstinklaserphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT michelaantonelliphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT alexanderhammersphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT timspectorfrcpphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT sebastienourselinphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT clairestevesmrcpphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT carolehsudrephd disentanglingpostvaccinationsymptomsfromearlycovid19 AT marcmodatphd disentanglingpostvaccinationsymptomsfromearlycovid19 AT emmalduncanfracpphd disentanglingpostvaccinationsymptomsfromearlycovid19
_version_	1718372912700850176

Disentangling post-vaccination symptoms from early COVID-19

Ejemplares similares