Lifespan mental activity predicts diminished rate of hippocampal atrophy.

<h4>Objective</h4>Epidemiological studies suggest that complex mental activity may reduce the risk for dementia, however an underlying mechanism remains unclear. Our objective was to determine whether individual differences in lifespan complex mental activity are linked to altered rates...

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Autores principales:	Michael J Valenzuela, Perminder Sachdev, Wei Wen, Xiaohua Chen, Henry Brodaty
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c698bf854764612998e827e3ac00772
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spelling	oai:doaj.org-article:5c698bf854764612998e827e3ac007722021-11-25T06:11:45ZLifespan mental activity predicts diminished rate of hippocampal atrophy.1932-620310.1371/journal.pone.0002598https://doaj.org/article/5c698bf854764612998e827e3ac007722008-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18612379/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Epidemiological studies suggest that complex mental activity may reduce the risk for dementia, however an underlying mechanism remains unclear. Our objective was to determine whether individual differences in lifespan complex mental activity are linked to altered rates of hippocampal atrophy independent of global measures of neurodegeneration.<h4>Methods</h4>Thirty seven healthy older individuals had their complex mental activity levels estimated using the Lifetime of Experiences Questionnaire (LEQ) and completed serial MRI investigations at baseline and three years follow-up. Hippocampal volume and semi-automatic quantitation of whole brain volume (WBV) and white matter hyperintensities (WMHs) were compared at both time points.<h4>Results</h4>Higher LEQ scores were correlated with hippocampal volume independent of covariates at the three year follow-up stage (r = 0.43, p = 0.012). Moreover, those with higher LEQ scores experienced less hippocampal atrophy over the follow-up period (r = 0.41, p = 0.02). High LEQ individuals had less than half the hippocampal volume decline of low LEQ individuals in a multivariate analysis (F = 4.47, p = 0.042). No parallel changes were found in measures of WBV and WMHs.<h4>Conclusions</h4>High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy. This finding could not be explained by general differences in intracranial volume, larger hippocampi at baseline, presence of hypertensive disease, gender or low mood. Our results suggest that neuroprotection in medial temporal lobe may be one mechanism underlying the link between mental activity and lower rates of dementia observed in population-based studies. Additional studies are required to further explore this novel finding.Michael J ValenzuelaPerminder SachdevWei WenXiaohua ChenHenry BrodatyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 3, Iss 7, p e2598 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael J Valenzuela Perminder Sachdev Wei Wen Xiaohua Chen Henry Brodaty Lifespan mental activity predicts diminished rate of hippocampal atrophy.
description	<h4>Objective</h4>Epidemiological studies suggest that complex mental activity may reduce the risk for dementia, however an underlying mechanism remains unclear. Our objective was to determine whether individual differences in lifespan complex mental activity are linked to altered rates of hippocampal atrophy independent of global measures of neurodegeneration.<h4>Methods</h4>Thirty seven healthy older individuals had their complex mental activity levels estimated using the Lifetime of Experiences Questionnaire (LEQ) and completed serial MRI investigations at baseline and three years follow-up. Hippocampal volume and semi-automatic quantitation of whole brain volume (WBV) and white matter hyperintensities (WMHs) were compared at both time points.<h4>Results</h4>Higher LEQ scores were correlated with hippocampal volume independent of covariates at the three year follow-up stage (r = 0.43, p = 0.012). Moreover, those with higher LEQ scores experienced less hippocampal atrophy over the follow-up period (r = 0.41, p = 0.02). High LEQ individuals had less than half the hippocampal volume decline of low LEQ individuals in a multivariate analysis (F = 4.47, p = 0.042). No parallel changes were found in measures of WBV and WMHs.<h4>Conclusions</h4>High level of complex mental activity across the lifespan was correlated with a reduced rate of hippocampal atrophy. This finding could not be explained by general differences in intracranial volume, larger hippocampi at baseline, presence of hypertensive disease, gender or low mood. Our results suggest that neuroprotection in medial temporal lobe may be one mechanism underlying the link between mental activity and lower rates of dementia observed in population-based studies. Additional studies are required to further explore this novel finding.
format	article
author	Michael J Valenzuela Perminder Sachdev Wei Wen Xiaohua Chen Henry Brodaty
author_facet	Michael J Valenzuela Perminder Sachdev Wei Wen Xiaohua Chen Henry Brodaty
author_sort	Michael J Valenzuela
title	Lifespan mental activity predicts diminished rate of hippocampal atrophy.
title_short	Lifespan mental activity predicts diminished rate of hippocampal atrophy.
title_full	Lifespan mental activity predicts diminished rate of hippocampal atrophy.
title_fullStr	Lifespan mental activity predicts diminished rate of hippocampal atrophy.
title_full_unstemmed	Lifespan mental activity predicts diminished rate of hippocampal atrophy.
title_sort	lifespan mental activity predicts diminished rate of hippocampal atrophy.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/5c698bf854764612998e827e3ac00772
work_keys_str_mv	AT michaeljvalenzuela lifespanmentalactivitypredictsdiminishedrateofhippocampalatrophy AT permindersachdev lifespanmentalactivitypredictsdiminishedrateofhippocampalatrophy AT weiwen lifespanmentalactivitypredictsdiminishedrateofhippocampalatrophy AT xiaohuachen lifespanmentalactivitypredictsdiminishedrateofhippocampalatrophy AT henrybrodaty lifespanmentalactivitypredictsdiminishedrateofhippocampalatrophy
_version_	1718414042865860608

Lifespan mental activity predicts diminished rate of hippocampal atrophy.

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