Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition

Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes and are often complexed with centrosome-related structures. Since their discovery, centrins have attracted increasing interest due to their multiple, diverse cellular functions. Centrins are similar to calmo...

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Autores principales:	Marco Pedretti, Luca Bombardi, Carolina Conter, Filippo Favretto, Paola Dominici, Alessandra Astegno
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	centrin EF-hand calcium signaling calcium binding protein protein interaction Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/5c6aa7a7013a4aa2bd96311c4d780603
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spelling	oai:doaj.org-article:5c6aa7a7013a4aa2bd96311c4d7806032021-11-25T17:53:58ZStructural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition10.3390/ijms2222121731422-00671661-6596https://doaj.org/article/5c6aa7a7013a4aa2bd96311c4d7806032021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12173https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes and are often complexed with centrosome-related structures. Since their discovery, centrins have attracted increasing interest due to their multiple, diverse cellular functions. Centrins are similar to calmodulin (CaM) in size, structure and domain organization, although in contrast to CaM, the majority of centrins possess at least one calcium (Ca<sup>2+</sup>) binding site that is non-functional, thus displaying large variance in Ca<sup>2+</sup> sensing abilities that could support their functional versatility. In this review, we summarize current knowledge on centrins from both biophysical and structural perspectives with an emphasis on centrin-target interactions. In-depth analysis of the Ca<sup>2+</sup> sensing properties of centrins and structures of centrins complexed with target proteins can provide useful insight into the mechanisms of the different functions of centrins and how these proteins contribute to the complexity of the Ca<sup>2+</sup> signaling cascade. Moreover, it can help to better understand the functional redundancy of centrin isoforms and centrin-binding proteins.Marco PedrettiLuca BombardiCarolina ConterFilippo FavrettoPaola DominiciAlessandra AstegnoMDPI AGarticlecentrinEF-handcalcium signalingcalcium binding proteinprotein interactionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12173, p 12173 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	centrin EF-hand calcium signaling calcium binding protein protein interaction Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	centrin EF-hand calcium signaling calcium binding protein protein interaction Biology (General) QH301-705.5 Chemistry QD1-999 Marco Pedretti Luca Bombardi Carolina Conter Filippo Favretto Paola Dominici Alessandra Astegno Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
description	Centrins are a family of small, EF hand-containing proteins that are found in all eukaryotes and are often complexed with centrosome-related structures. Since their discovery, centrins have attracted increasing interest due to their multiple, diverse cellular functions. Centrins are similar to calmodulin (CaM) in size, structure and domain organization, although in contrast to CaM, the majority of centrins possess at least one calcium (Ca<sup>2+</sup>) binding site that is non-functional, thus displaying large variance in Ca<sup>2+</sup> sensing abilities that could support their functional versatility. In this review, we summarize current knowledge on centrins from both biophysical and structural perspectives with an emphasis on centrin-target interactions. In-depth analysis of the Ca<sup>2+</sup> sensing properties of centrins and structures of centrins complexed with target proteins can provide useful insight into the mechanisms of the different functions of centrins and how these proteins contribute to the complexity of the Ca<sup>2+</sup> signaling cascade. Moreover, it can help to better understand the functional redundancy of centrin isoforms and centrin-binding proteins.
format	article
author	Marco Pedretti Luca Bombardi Carolina Conter Filippo Favretto Paola Dominici Alessandra Astegno
author_facet	Marco Pedretti Luca Bombardi Carolina Conter Filippo Favretto Paola Dominici Alessandra Astegno
author_sort	Marco Pedretti
title	Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
title_short	Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
title_full	Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
title_fullStr	Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
title_full_unstemmed	Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition
title_sort	structural basis for the functional diversity of centrins: a focus on calcium sensing properties and target recognition
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5c6aa7a7013a4aa2bd96311c4d780603
work_keys_str_mv	AT marcopedretti structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition AT lucabombardi structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition AT carolinaconter structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition AT filippofavretto structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition AT paoladominici structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition AT alessandraastegno structuralbasisforthefunctionaldiversityofcentrinsafocusoncalciumsensingpropertiesandtargetrecognition
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Structural Basis for the Functional Diversity of Centrins: A Focus on Calcium Sensing Properties and Target Recognition

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