The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.

<h4>Background</h4>Studies have reported agreement between computed tomography (CT) and renography for the determination of split kidney function. However, their correlation with post-donation kidney function remains unclear. We compared CT measurements with renography in assessment of s...

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Autores principales:	Kelly C Harper, Jean-Paul Salameh, Natasha Akhlaq, Matthew D F McInnes, Victoria Ivankovic, Mahdi H Beydoun, Edward G Clark, Wanzhen Zeng, Brian D M Blew, Kevin D Burns, Manish M Sood, Ann Bugeja
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c6aa8dc8466490e9e31109c978d7832
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spelling	oai:doaj.org-article:5c6aa8dc8466490e9e31109c978d78322021-12-02T20:15:40ZThe impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.1932-620310.1371/journal.pone.0253609https://doaj.org/article/5c6aa8dc8466490e9e31109c978d78322021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253609https://doaj.org/toc/1932-6203<h4>Background</h4>Studies have reported agreement between computed tomography (CT) and renography for the determination of split kidney function. However, their correlation with post-donation kidney function remains unclear. We compared CT measurements with renography in assessment of split kidney function (SKF) and their correlations with post-donation kidney function.<h4>Methods</h4>A single-centre, retrospective cohort study of 248 donors from January 1, 2009-July 31, 2019 were assessed. Pearson correlations were used to assess post-donation kidney function with renography and CT-based measurements. Furthermore, we examined high risk groups with SKF difference greater than 10% on renography and donors with post-donation eGFR less than 60 mL/min/1.73m2.<h4>Results</h4>62% of donors were women with a mean (standard deviation) pre-donation eGFR 99 (20) and post-donation eGFR 67 (22) mL/min/1.73m2 at 31 months of follow-up. Post-donation kidney function was poorly correlated with both CT-based measurements and renography, including the subgroup of donors with post-donation eGFR less than 60 mL/min/1.73m2 (r less than 0.4 for all). There was agreement between CT-based measurements and renography for SKF determination (Bland-Altman agreement [bias, 95% limits of agreement] for renography vs: CT volume, 0.76%, -7.60-9.15%; modified ellipsoid,1.01%, -8.38-10.42%; CC dimension, 0.44%, -7.06-7.94); however, CT missed SKF greater than 10% found by renography in 20 out 26 (77%) of donors.<h4>Conclusions</h4>In a single centre study of 248 living donors, we found no correlation between CT or renography and post-donation eGFR. Further research is needed to determine optimal ways to predict remaining kidney function after donation.Kelly C HarperJean-Paul SalamehNatasha AkhlaqMatthew D F McInnesVictoria IvankovicMahdi H BeydounEdward G ClarkWanzhen ZengBrian D M BlewKevin D BurnsManish M SoodAnn BugejaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253609 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kelly C Harper Jean-Paul Salameh Natasha Akhlaq Matthew D F McInnes Victoria Ivankovic Mahdi H Beydoun Edward G Clark Wanzhen Zeng Brian D M Blew Kevin D Burns Manish M Sood Ann Bugeja The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
description	<h4>Background</h4>Studies have reported agreement between computed tomography (CT) and renography for the determination of split kidney function. However, their correlation with post-donation kidney function remains unclear. We compared CT measurements with renography in assessment of split kidney function (SKF) and their correlations with post-donation kidney function.<h4>Methods</h4>A single-centre, retrospective cohort study of 248 donors from January 1, 2009-July 31, 2019 were assessed. Pearson correlations were used to assess post-donation kidney function with renography and CT-based measurements. Furthermore, we examined high risk groups with SKF difference greater than 10% on renography and donors with post-donation eGFR less than 60 mL/min/1.73m2.<h4>Results</h4>62% of donors were women with a mean (standard deviation) pre-donation eGFR 99 (20) and post-donation eGFR 67 (22) mL/min/1.73m2 at 31 months of follow-up. Post-donation kidney function was poorly correlated with both CT-based measurements and renography, including the subgroup of donors with post-donation eGFR less than 60 mL/min/1.73m2 (r less than 0.4 for all). There was agreement between CT-based measurements and renography for SKF determination (Bland-Altman agreement [bias, 95% limits of agreement] for renography vs: CT volume, 0.76%, -7.60-9.15%; modified ellipsoid,1.01%, -8.38-10.42%; CC dimension, 0.44%, -7.06-7.94); however, CT missed SKF greater than 10% found by renography in 20 out 26 (77%) of donors.<h4>Conclusions</h4>In a single centre study of 248 living donors, we found no correlation between CT or renography and post-donation eGFR. Further research is needed to determine optimal ways to predict remaining kidney function after donation.
format	article
author	Kelly C Harper Jean-Paul Salameh Natasha Akhlaq Matthew D F McInnes Victoria Ivankovic Mahdi H Beydoun Edward G Clark Wanzhen Zeng Brian D M Blew Kevin D Burns Manish M Sood Ann Bugeja
author_facet	Kelly C Harper Jean-Paul Salameh Natasha Akhlaq Matthew D F McInnes Victoria Ivankovic Mahdi H Beydoun Edward G Clark Wanzhen Zeng Brian D M Blew Kevin D Burns Manish M Sood Ann Bugeja
author_sort	Kelly C Harper
title	The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
title_short	The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
title_full	The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
title_fullStr	The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
title_full_unstemmed	The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.
title_sort	impact of measuring split kidney function on post-donation kidney function: a retrospective cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/5c6aa8dc8466490e9e31109c978d7832
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The impact of measuring split kidney function on post-donation kidney function: A retrospective cohort study.

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