Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.

Toll-like receptor 4 deficiency accelerates the development of insulin-deficient diabetes in non-obese diabetic mice.

<h4>Background/objective</h4>Toll-like receptors (TLR) mediate the recognition of microbial constituents and stress-induced endogenous ligands by the immune system. They may also be involved in the maintenance or break down of tolerance against autologous antigens. The aim of our investi...

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Autores principales: Elke Gülden, Masaru Ihira, Atsushi Ohashi, Anna Lena Reinbeck, Marina A Freudenberg, Hubert Kolb, Volker Burkart
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/5c6aea1a33e14d68962e75adc416e65c
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