Changes in behavior as side effects in methylphenidate treatment: review of the literature

Doris Susanne Konrad-Bindl,1 Ursula Gresser,1 Barbara Maria Richartz2 1Department of Internal Medicine, University of Munich, Munich, 2Clinic der Jägerwinkel, Bad Wiessee, Germany Background: Our review of the scientific literature focused on an analysis of studies describing ins...

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Autores principales:	Konrad-Bindl DS, Gresser U, Richartz BM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Methylphenidate changes in behavior attention deficit hyperactivity disorder children adults adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5c6b6e1ca2234d05a4401f67e40e93f7
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spelling	oai:doaj.org-article:5c6b6e1ca2234d05a4401f67e40e93f72021-12-02T02:27:10ZChanges in behavior as side effects in methylphenidate treatment: review of the literature1178-2021https://doaj.org/article/5c6b6e1ca2234d05a4401f67e40e93f72016-10-01T00:00:00Zhttps://www.dovepress.com/changes-in-behavior-as-side-effects-in-methylphenidate-treatment-revie-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Doris Susanne Konrad-Bindl,1 Ursula Gresser,1 Barbara Maria Richartz2 1Department of Internal Medicine, University of Munich, Munich, 2Clinic der Jägerwinkel, Bad Wiessee, Germany Background: Our review of the scientific literature focused on an analysis of studies describing instances of methylphenidate treatment leading (or not) to behavioral changes in the pediatric, adolescent, and adult populations.Materials and methods: We conducted a literature search in PubMed, Medline, and Google using the keywords “methylphenidate”, “behavioral changes”, “adverse effects”, and “side effects”. A total of 44 studies were identified as reporting on the effects and adverse effects of methylphenidate administration, and were included in the analysis.Results: Five studies specifically set out to study, record, and discuss changes in behavior. Eight studies did not set out to study behavioral effects, but record and discuss them. A total of 28 studies recorded behavioral effects, but failed to discuss these further. Three studies did not include behavioral effects.Conclusion: This review records what data have been published in respect of changes in behavior in association with the use of methylphenidate. While there is some evidence to suggest that methylphenidate causes changes in behavior, the majority of the studies reviewed paid little or no attention to this issue. Based on the available data, it is impossible to determine the point at which such behavioral effects occur. The frequency of occurrence of behavioral effects is also impossible to determine with certainty. Based on the available data, it is not possible to rule out whether behavioral effects may persist or not persist once treatment is discontinued. In conclusion, despite countless publications and extensive administration, especially to children, we have insufficient data to judge the long-term effects and risks of methylphenidate taking. Keywords: methylphenidate, changes in behavior, attention-deficit/hyperactivity disorder, children, adults, adverse effectsKonrad-Bindl DSGresser URichartz BMDove Medical PressarticleMethylphenidatechanges in behaviorattention deficit hyperactivity disorderchildrenadultsadverse effectsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 12, Pp 2635-2647 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Methylphenidate changes in behavior attention deficit hyperactivity disorder children adults adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Methylphenidate changes in behavior attention deficit hyperactivity disorder children adults adverse effects Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Konrad-Bindl DS Gresser U Richartz BM Changes in behavior as side effects in methylphenidate treatment: review of the literature
description	Doris Susanne Konrad-Bindl,1 Ursula Gresser,1 Barbara Maria Richartz2 1Department of Internal Medicine, University of Munich, Munich, 2Clinic der Jägerwinkel, Bad Wiessee, Germany Background: Our review of the scientific literature focused on an analysis of studies describing instances of methylphenidate treatment leading (or not) to behavioral changes in the pediatric, adolescent, and adult populations.Materials and methods: We conducted a literature search in PubMed, Medline, and Google using the keywords “methylphenidate”, “behavioral changes”, “adverse effects”, and “side effects”. A total of 44 studies were identified as reporting on the effects and adverse effects of methylphenidate administration, and were included in the analysis.Results: Five studies specifically set out to study, record, and discuss changes in behavior. Eight studies did not set out to study behavioral effects, but record and discuss them. A total of 28 studies recorded behavioral effects, but failed to discuss these further. Three studies did not include behavioral effects.Conclusion: This review records what data have been published in respect of changes in behavior in association with the use of methylphenidate. While there is some evidence to suggest that methylphenidate causes changes in behavior, the majority of the studies reviewed paid little or no attention to this issue. Based on the available data, it is impossible to determine the point at which such behavioral effects occur. The frequency of occurrence of behavioral effects is also impossible to determine with certainty. Based on the available data, it is not possible to rule out whether behavioral effects may persist or not persist once treatment is discontinued. In conclusion, despite countless publications and extensive administration, especially to children, we have insufficient data to judge the long-term effects and risks of methylphenidate taking. Keywords: methylphenidate, changes in behavior, attention-deficit/hyperactivity disorder, children, adults, adverse effects
format	article
author	Konrad-Bindl DS Gresser U Richartz BM
author_facet	Konrad-Bindl DS Gresser U Richartz BM
author_sort	Konrad-Bindl DS
title	Changes in behavior as side effects in methylphenidate treatment: review of the literature
title_short	Changes in behavior as side effects in methylphenidate treatment: review of the literature
title_full	Changes in behavior as side effects in methylphenidate treatment: review of the literature
title_fullStr	Changes in behavior as side effects in methylphenidate treatment: review of the literature
title_full_unstemmed	Changes in behavior as side effects in methylphenidate treatment: review of the literature
title_sort	changes in behavior as side effects in methylphenidate treatment: review of the literature
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5c6b6e1ca2234d05a4401f67e40e93f7
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Changes in behavior as side effects in methylphenidate treatment: review of the literature

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