Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cells and that HER3 inhibition increases response to P...

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Autores principales:	Zhiyong Wang, Yusuke Goto, Michael M. Allevato, Victoria H. Wu, Robert Saddawi-Konefka, Mara Gilardi, Diego Alvarado, Bryan S. Yung, Aoife O’Farrell, Alfredo A. Molinolo, Umamaheswar Duvvuri, Jennifer R. Grandis, Joseph A. Califano, Ezra E. W. Cohen, J. Silvio Gutkind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5c6d1bf166824a7299c38c08b6124d71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:5c6d1bf166824a7299c38c08b6124d712021-12-02T13:39:22ZDisruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer10.1038/s41467-021-22619-w2041-1723https://doaj.org/article/5c6d1bf166824a7299c38c08b6124d712021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22619-whttps://doaj.org/toc/2041-1723There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cells and that HER3 inhibition increases response to PD-1 blockade in HNSCC preclinical models.Zhiyong WangYusuke GotoMichael M. AllevatoVictoria H. WuRobert Saddawi-KonefkaMara GilardiDiego AlvaradoBryan S. YungAoife O’FarrellAlfredo A. MolinoloUmamaheswar DuvvuriJennifer R. GrandisJoseph A. CalifanoEzra E. W. CohenJ. Silvio GutkindNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhiyong Wang Yusuke Goto Michael M. Allevato Victoria H. Wu Robert Saddawi-Konefka Mara Gilardi Diego Alvarado Bryan S. Yung Aoife O’Farrell Alfredo A. Molinolo Umamaheswar Duvvuri Jennifer R. Grandis Joseph A. Califano Ezra E. W. Cohen J. Silvio Gutkind Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
description	There is an unmet need to improve the response to immune checkpoint blockade in patients with head and neck squamous cell carcinoma (HNSCC). Here the authors show that aberrant HER3 activation sustains the proliferation of PIK3CA wild type HNSCC cells and that HER3 inhibition increases response to PD-1 blockade in HNSCC preclinical models.
format	article
author	Zhiyong Wang Yusuke Goto Michael M. Allevato Victoria H. Wu Robert Saddawi-Konefka Mara Gilardi Diego Alvarado Bryan S. Yung Aoife O’Farrell Alfredo A. Molinolo Umamaheswar Duvvuri Jennifer R. Grandis Joseph A. Califano Ezra E. W. Cohen J. Silvio Gutkind
author_facet	Zhiyong Wang Yusuke Goto Michael M. Allevato Victoria H. Wu Robert Saddawi-Konefka Mara Gilardi Diego Alvarado Bryan S. Yung Aoife O’Farrell Alfredo A. Molinolo Umamaheswar Duvvuri Jennifer R. Grandis Joseph A. Califano Ezra E. W. Cohen J. Silvio Gutkind
author_sort	Zhiyong Wang
title	Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
title_short	Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
title_full	Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
title_fullStr	Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
title_full_unstemmed	Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
title_sort	disruption of the her3-pi3k-mtor oncogenic signaling axis and pd-1 blockade as a multimodal precision immunotherapy in head and neck cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c6d1bf166824a7299c38c08b6124d71
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Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer

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