ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE

Objective: To compare mean heart rate reduction in Ivabradine and placebo group in left ventricular failure patients. Study Design: Quasi experimental study. Place and Duration of Study: Study was conducted at CMH, Kharian, from Jul 2018 to Dec 2018. Methodology: 64 patients participated i...

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Autores principales:	Safia Batool, Jamal Waris, Muhammad Usman Sajid, Shazia Nisar, Imran Khan, Hina Mushtaq
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	heart rate ivabradine left ventricular failure Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c721ef91d3e495f8c8a5120fcf88bf7
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spelling	oai:doaj.org-article:5c721ef91d3e495f8c8a5120fcf88bf72021-12-02T14:54:22ZROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILUREdoi.org/10.51253/pafmj.v70i6.48690030-96482411-8842https://doaj.org/article/5c721ef91d3e495f8c8a5120fcf88bf72020-12-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/4869https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare mean heart rate reduction in Ivabradine and placebo group in left ventricular failure patients. Study Design: Quasi experimental study. Place and Duration of Study: Study was conducted at CMH, Kharian, from Jul 2018 to Dec 2018. Methodology: 64 patients participated in the study. They were randomly divided into two groups of 32 each. One group was given Tab Ivabradine (10 mg twice a day) while second group received a placebo for a period of 4 weeks. After 4 weeks each patient was evaluated and heart rate, systolic and diastolic blood pressure were recorded. Mann-whitney U test selected to compare heart rate and ages of both groups t- test used to compare systolic and diastolic blood pressure among both groups. Chi-square test used to determine the association of heart rate between two groups. A p-value ≤0.05 was considered significant. Results: Median (IQR) heart rate was significantly lower in Ivabradine group 58.3 (4) as compared to placebo 64.1(1) (p<0.01). Systolic blood pressure (132.8 ± 3.6) was significantly lower in ivabradine group as compared to placebo group (137.1 ± 4.5) (p<0.01). Difference in diastolic blood pressure was insignificant in both groups (p=0.55). There was a significant association between heart rate of 55-60 beats per minute and ivabradine use (p<0.01). Conclusion: Ivabradine is safe and efficative drug in reducing heart rate and systolic blood pressure for patients suffering from left ventricular failure. Early detection and management of left ventricular failure with ivabradine use leads to better prognosis of the disease.Safia BatoolJamal WarisMuhammad Usman SajidShazia NisarImran KhanHina MushtaqArmy Medical College Rawalpindiarticleheart rateivabradineleft ventricular failureMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 6, Pp 1839-1842 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart rate ivabradine left ventricular failure Medicine R Medicine (General) R5-920
spellingShingle	heart rate ivabradine left ventricular failure Medicine R Medicine (General) R5-920 Safia Batool Jamal Waris Muhammad Usman Sajid Shazia Nisar Imran Khan Hina Mushtaq ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
description	Objective: To compare mean heart rate reduction in Ivabradine and placebo group in left ventricular failure patients. Study Design: Quasi experimental study. Place and Duration of Study: Study was conducted at CMH, Kharian, from Jul 2018 to Dec 2018. Methodology: 64 patients participated in the study. They were randomly divided into two groups of 32 each. One group was given Tab Ivabradine (10 mg twice a day) while second group received a placebo for a period of 4 weeks. After 4 weeks each patient was evaluated and heart rate, systolic and diastolic blood pressure were recorded. Mann-whitney U test selected to compare heart rate and ages of both groups t- test used to compare systolic and diastolic blood pressure among both groups. Chi-square test used to determine the association of heart rate between two groups. A p-value ≤0.05 was considered significant. Results: Median (IQR) heart rate was significantly lower in Ivabradine group 58.3 (4) as compared to placebo 64.1(1) (p<0.01). Systolic blood pressure (132.8 ± 3.6) was significantly lower in ivabradine group as compared to placebo group (137.1 ± 4.5) (p<0.01). Difference in diastolic blood pressure was insignificant in both groups (p=0.55). There was a significant association between heart rate of 55-60 beats per minute and ivabradine use (p<0.01). Conclusion: Ivabradine is safe and efficative drug in reducing heart rate and systolic blood pressure for patients suffering from left ventricular failure. Early detection and management of left ventricular failure with ivabradine use leads to better prognosis of the disease.
format	article
author	Safia Batool Jamal Waris Muhammad Usman Sajid Shazia Nisar Imran Khan Hina Mushtaq
author_facet	Safia Batool Jamal Waris Muhammad Usman Sajid Shazia Nisar Imran Khan Hina Mushtaq
author_sort	Safia Batool
title	ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
title_short	ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
title_full	ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
title_fullStr	ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
title_full_unstemmed	ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE
title_sort	role of heart rate reduction with ivabradine in left ventricular failure
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/5c721ef91d3e495f8c8a5120fcf88bf7
work_keys_str_mv	AT safiabatool roleofheartratereductionwithivabradineinleftventricularfailure AT jamalwaris roleofheartratereductionwithivabradineinleftventricularfailure AT muhammadusmansajid roleofheartratereductionwithivabradineinleftventricularfailure AT shazianisar roleofheartratereductionwithivabradineinleftventricularfailure AT imrankhan roleofheartratereductionwithivabradineinleftventricularfailure AT hinamushtaq roleofheartratereductionwithivabradineinleftventricularfailure
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ROLE OF HEART RATE REDUCTION WITH IVABRADINE IN LEFT VENTRICULAR FAILURE

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