Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites

Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, Division of Engineering, Brown University, Providence, RI, USAAbstract: Nanomaterials offer a number of properties that are of interest to the field of neural tissue engineering. Specifically, materials that exhibit nanoscale surfa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Justin T Seil, Thomas J Webster
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c7999a359374c749b94ae1c64aab548
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c7999a359374c749b94ae1c64aab548
record_format	dspace
spelling	oai:doaj.org-article:5c7999a359374c749b94ae1c64aab5482021-12-02T05:49:32ZDecreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites1176-91141178-2013https://doaj.org/article/5c7999a359374c749b94ae1c64aab5482008-11-01T00:00:00Zhttp://www.dovepress.com/decreased-astroglial-cell-adhesion-and-proliferation-on-zinc-oxide-nan-a2648https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, Division of Engineering, Brown University, Providence, RI, USAAbstract: Nanomaterials offer a number of properties that are of interest to the field of neural tissue engineering. Specifically, materials that exhibit nanoscale surface dimensions have been shown to promote neuron function while simultaneously minimizing the activity of cells such as astrocytes that inhibit central nervous system regeneration. Studies demonstrating enhanced neural tissue regeneration in electrical fields through the use of conductive materials have led to interest in piezoelectric materials (or those materials which generate a transient electrical potential when mechanically deformed) such as zinc oxide (ZnO). It has been speculated that ZnO nanoparticles possess increased piezoelectric properties over ZnO micron particles. Due to this promise in neural applications, the objective of the present in vitro study was, for the first time, to assess the activity of astroglial cells on ZnO nanoparticle polymer composites. ZnO nanoparticles embedded in polyurethane were analyzed via scanning electron microscopy to evaluate nanoscale surface features of the composites. The surface chemistry was characterized via X-ray photoelectron spectroscopy. Astroglial cell response was evaluated based on cell adhesion and proliferation. Astrocyte adhesion was significantly reduced on ZnO nanoparticle/polyurethane (PU) composites with a weight ratio of 50:50 (PU:ZnO) wt.%, 75:25 (PU:ZnO) wt.%, and 90:10 (PU:ZnO) wt.% in comparison to pure PU. The successful production of ZnO nanoparticle composite scaffolds suitable for decreasing astroglial cell density demonstrates their potential as a nerve guidance channel material with greater efficiency than what may be available today.Keywords: zinc oxide, nanoparticles, astrocytes, neural tissue, nervous system, biomaterials Justin T SeilThomas J WebsterDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 523-531 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Justin T Seil Thomas J Webster Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
description	Justin T Seil, Thomas J WebsterLaboratory for Nanomedicine Research, Division of Engineering, Brown University, Providence, RI, USAAbstract: Nanomaterials offer a number of properties that are of interest to the field of neural tissue engineering. Specifically, materials that exhibit nanoscale surface dimensions have been shown to promote neuron function while simultaneously minimizing the activity of cells such as astrocytes that inhibit central nervous system regeneration. Studies demonstrating enhanced neural tissue regeneration in electrical fields through the use of conductive materials have led to interest in piezoelectric materials (or those materials which generate a transient electrical potential when mechanically deformed) such as zinc oxide (ZnO). It has been speculated that ZnO nanoparticles possess increased piezoelectric properties over ZnO micron particles. Due to this promise in neural applications, the objective of the present in vitro study was, for the first time, to assess the activity of astroglial cells on ZnO nanoparticle polymer composites. ZnO nanoparticles embedded in polyurethane were analyzed via scanning electron microscopy to evaluate nanoscale surface features of the composites. The surface chemistry was characterized via X-ray photoelectron spectroscopy. Astroglial cell response was evaluated based on cell adhesion and proliferation. Astrocyte adhesion was significantly reduced on ZnO nanoparticle/polyurethane (PU) composites with a weight ratio of 50:50 (PU:ZnO) wt.%, 75:25 (PU:ZnO) wt.%, and 90:10 (PU:ZnO) wt.% in comparison to pure PU. The successful production of ZnO nanoparticle composite scaffolds suitable for decreasing astroglial cell density demonstrates their potential as a nerve guidance channel material with greater efficiency than what may be available today.Keywords: zinc oxide, nanoparticles, astrocytes, neural tissue, nervous system, biomaterials
format	article
author	Justin T Seil Thomas J Webster
author_facet	Justin T Seil Thomas J Webster
author_sort	Justin T Seil
title	Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
title_short	Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
title_full	Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
title_fullStr	Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
title_full_unstemmed	Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
title_sort	decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/5c7999a359374c749b94ae1c64aab548
work_keys_str_mv	AT justintseil decreasedastroglialcelladhesionandproliferationonzincoxidenanoparticlepolyurethanecomposites AT thomasjwebster decreasedastroglialcelladhesionandproliferationonzincoxidenanoparticlepolyurethanecomposites
_version_	1718400231530299392

Decreased astroglial cell adhesion and proliferation on zinc oxide nanoparticle polyurethane composites

Ejemplares similares