Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients

Abstract Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent he...

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Autores principales:	Ali Bohlok, Peter Vermeulen, Sophia Leduc, Emily Latacz, Lara Botzenhart, François Richard, Maxim De Schepper, Tatjana Geukens, Valerio Lucidi, Michail Ignatiadis, Philippe Aftimos, Christos Sotiriou, Martine Piccart, Alain Hendlisz, Steven Van Laere, Luc Dirix, Jean-Christophe Noël, Elia Biganzoli, Denis Larsimont, Christine Desmedt, Vincent Donckier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5c79b68166d04ad68699b274c384a172
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spelling	oai:doaj.org-article:5c79b68166d04ad68699b274c384a1722021-12-02T13:56:04ZAssociation between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients10.1038/s41523-020-00209-12374-4677https://doaj.org/article/5c79b68166d04ad68699b274c384a1722020-12-01T00:00:00Zhttps://doi.org/10.1038/s41523-020-00209-1https://doaj.org/toc/2374-4677Abstract Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).Ali BohlokPeter VermeulenSophia LeducEmily LataczLara BotzenhartFrançois RichardMaxim De SchepperTatjana GeukensValerio LucidiMichail IgnatiadisPhilippe AftimosChristos SotiriouMartine PiccartAlain HendliszSteven Van LaereLuc DirixJean-Christophe NoëlElia BiganzoliDenis LarsimontChristine DesmedtVincent DonckierNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 6, Iss 1, Pp 1-5 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ali Bohlok Peter Vermeulen Sophia Leduc Emily Latacz Lara Botzenhart François Richard Maxim De Schepper Tatjana Geukens Valerio Lucidi Michail Ignatiadis Philippe Aftimos Christos Sotiriou Martine Piccart Alain Hendlisz Steven Van Laere Luc Dirix Jean-Christophe Noël Elia Biganzoli Denis Larsimont Christine Desmedt Vincent Donckier Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
description	Abstract Currently, there are no markers to identify patients with liver-only or liver-dominant metastases that would benefit from hepatic surgery. Here we characterized histopathological growth patterns (HGPs) of liver metastases in a consecutive series of 36 breast cancer patients who underwent hepatic surgery. Survival analyses showed that the presence of a desmoplastic HGP in the liver metastases (a rim of fibrous tissue separating cancer cells from the liver parenchyma, present in 20 (56%) patients) is independently associated with favorable progression-free and overall survival when compared with the replacement HGP (cancer cells growing into the liver parenchyma, present in 16 (44%) patients).
format	article
author	Ali Bohlok Peter Vermeulen Sophia Leduc Emily Latacz Lara Botzenhart François Richard Maxim De Schepper Tatjana Geukens Valerio Lucidi Michail Ignatiadis Philippe Aftimos Christos Sotiriou Martine Piccart Alain Hendlisz Steven Van Laere Luc Dirix Jean-Christophe Noël Elia Biganzoli Denis Larsimont Christine Desmedt Vincent Donckier
author_facet	Ali Bohlok Peter Vermeulen Sophia Leduc Emily Latacz Lara Botzenhart François Richard Maxim De Schepper Tatjana Geukens Valerio Lucidi Michail Ignatiadis Philippe Aftimos Christos Sotiriou Martine Piccart Alain Hendlisz Steven Van Laere Luc Dirix Jean-Christophe Noël Elia Biganzoli Denis Larsimont Christine Desmedt Vincent Donckier
author_sort	Ali Bohlok
title	Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
title_short	Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
title_full	Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
title_fullStr	Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
title_full_unstemmed	Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
title_sort	association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5c79b68166d04ad68699b274c384a172
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Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients

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