Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization

Abstract Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ayele H. Negussie, Quirina M. B. de Ruiter, Hugh Britton, Danielle R. Donahue, Quentin Boffi, Young-Seung Kim, William F. Pritchard, Chrit Moonen, Gert Storm, Andrew L. Lewis, Bradford J. Wood
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5c8343e6e7924265820253b48addecee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c8343e6e7924265820253b48addecee
record_format	dspace
spelling	oai:doaj.org-article:5c8343e6e7924265820253b48addecee2021-12-02T14:12:42ZSynthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization10.1038/s41598-020-79900-z2045-2322https://doaj.org/article/5c8343e6e7924265820253b48addecee2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79900-zhttps://doaj.org/toc/2045-2322Abstract Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking.Ayele H. NegussieQuirina M. B. de RuiterHugh BrittonDanielle R. DonahueQuentin BoffiYoung-Seung KimWilliam F. PritchardChrit MoonenGert StormAndrew L. LewisBradford J. WoodNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ayele H. Negussie Quirina M. B. de Ruiter Hugh Britton Danielle R. Donahue Quentin Boffi Young-Seung Kim William F. Pritchard Chrit Moonen Gert Storm Andrew L. Lewis Bradford J. Wood Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
description	Abstract Current therapy for hypervascular cancers, e.g., hepatocellular carcinoma, includes occlusion of the tumor blood supply by arterial infusion of embolic microspheres (beads) suspended in iodine-based contrast under fluoroscopic guidance. Available radiopaque, imageable beads use iodine as the radiopacifier and cannot be differentiated from contrast. This study aimed to synthesize and characterize imageable beads using bismuth as the radiopacifier that could be distinguished from iodine contrast based upon the difference in the binding energy of k-shell electrons (k-edge). Radiodense bismuth beads were successfully synthesized some with uniform bismuth distribution across the beads. The beads were spherical and could be infused through clinical microcatheters. The bismuth beads could be imaged with clinical dual-energy computed tomography (CT), where iodine-based contrast could be distinguished from the microspheres. The ability to separate iodine from bismuth may enhance the diagnostic information acquired on follow-up CT, identifying the distribution of the embolic beads separately from the contrast. Furthermore, with sequential use of iodine- and bismuth-based beads, the two radiopaque beads could be spatially distinguished on imaging, which may enable the development of dual drug delivery and dual tracking.
format	article
author	Ayele H. Negussie Quirina M. B. de Ruiter Hugh Britton Danielle R. Donahue Quentin Boffi Young-Seung Kim William F. Pritchard Chrit Moonen Gert Storm Andrew L. Lewis Bradford J. Wood
author_facet	Ayele H. Negussie Quirina M. B. de Ruiter Hugh Britton Danielle R. Donahue Quentin Boffi Young-Seung Kim William F. Pritchard Chrit Moonen Gert Storm Andrew L. Lewis Bradford J. Wood
author_sort	Ayele H. Negussie
title	Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
title_short	Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
title_full	Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
title_fullStr	Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
title_full_unstemmed	Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
title_sort	synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5c8343e6e7924265820253b48addecee
work_keys_str_mv	AT ayelehnegussie synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT quirinambderuiter synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT hughbritton synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT daniellerdonahue synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT quentinboffi synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT youngseungkim synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT williamfpritchard synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT chritmoonen synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT gertstorm synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT andrewllewis synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization AT bradfordjwood synthesischaracterizationandimagingofradiopaquebismuthbeadsforimageguidedtransarterialembolization
_version_	1718391784185266176

Synthesis, characterization, and imaging of radiopaque bismuth beads for image-guided transarterial embolization

Ejemplares similares