A Multi-Center, Real-World Study of Chidamide for Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas in China

A Multi-Center, Real-World Study of Chidamide for Patients With Relapsed or Refractory Peripheral T-Cell Lymphomas in China

Chidamide has demonstrated significant clinical benefits for patients with relapsed/refractory (R/R) PTCL in previous studies. This multi-center observational study was aimed to evaluate the objective response rate (ORR), overall survival (OS), and safety of chidamide. From February 2015 to December...

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Autores principales: Weiping Liu, Donglu Zhao, Ting Liu, Ting Niu, Yongping Song, Wei Xu, Jie Jin, Qingqing Cai, Huiqiang Huang, Zhiming Li, Ming Hou, Huilai Zhang, Jianfeng Zhou, Jianda Hu, Jianzhen Shen, Yuankai Shi, Yu Yang, Liling Zhang, Weili Zhao, Kaiyang Ding, Lugui Qiu, Huo Tan, Zhihui Zhang, Lihong Liu, Jinghua Wang, Bing Xu, Hui Zhou, Guangxun Gao, Hongwei Xue, Ou Bai, Ru Feng, Xiaobing Huang, Haiyan Yang, Xiaojing Yan, Qingshu Zeng, Peng Liu, Wenyu Li, Min Mao, Hang Su, Xin Wang, Jingyan Xu, Daobin Zhou, Hongyu Zhang, Jun Ma, Zhixiang Shen, Jun Zhu
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
lymphoma
T-cell
peripheral
histone deacetylase inhibitors
efficiency
safety
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/5c9000aa953646639a5acb21ddd9d292
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Sumario:Chidamide has demonstrated significant clinical benefits for patients with relapsed/refractory (R/R) PTCL in previous studies. This multi-center observational study was aimed to evaluate the objective response rate (ORR), overall survival (OS), and safety of chidamide. From February 2015 to December 2017, 548 patients with R/R PTCL from 186 research centers in China were included in the study. Among the 261 patients treated with chidamide monotherapy, ORR was 58.6% and 55 patients (21.1%) achieved complete response (CR). Among the 287 patients receiving chidamide-containing combination therapies, ORR was 73.2% and 73 patients (25.4%) achieved CR. The median OS of all patients was 15.1 months. The median OS of patients receiving chidamide monotherapy and combination therapies was 433 and 463 days, respectively. These results demonstrate a significant survival advantage of chidamide treatments as compared with international historical records. Common adverse effects (AEs) were hematological toxicities. Most AEs in both monotherapy and combined treatments were grade 1–2. No unanticipated AEs occurred. In conclusion, chidamide-based therapy led to a favorable efficacy and survival benefit for R/R PTCL. Future studies should explore the potential advantage of chidamide treatment combined with chemotherapy.

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