Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode

Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of...

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Autores principales:	Apetrei IM, Apetrei C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	pyritinol carbon nanofiber gold nanoparticle sensor square-wave voltammetry Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5c9403418ebc4f048f95630f895c4ad1
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spelling	oai:doaj.org-article:5c9403418ebc4f048f95630f895c4ad12021-12-02T00:38:14ZHighly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode1178-2013https://doaj.org/article/5c9403418ebc4f048f95630f895c4ad12017-07-01T00:00:00Zhttps://www.dovepress.com/highly-sensitive-voltamperometric-determination-of-pyritinol-using-car-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Galati, Romania Abstract: A novel and highly sensitive electrochemical method for the detection of pyritinol in pharmaceutical products and serum samples has been accomplished based on voltamperometric response of pyritinol in carbon nanofiber-gold nanoparticle (CNF-GNP)-modified screen-printed carbon electrode (SPCE). The electrochemical response of pyritinol to CNF-GNP-modified SPCE was studied by cyclic voltammetry and square-wave voltammetry (SWV). Under optimized working conditions, the novel sensor shows excellent voltamperometric response toward pyritinol. The SWV study shows significantly enhanced electrochemical response for pyritinol in CNF-GNP-modified SPCE providing high sensitivity to the novel sensor for pyritinol detection. The peak current for pyritinol is found to be linear with the concentration in the range 1.0×10-8–5.0×10-5 M with a detection limit of 6.23×10-9 M using SWV as the detection method. The viability of the new developed sensor for the analytical purposes was studied by performing experiments on various commercial pharmaceutical products and blood serum samples, which yielded adequate recoveries of pyritinol. The novel electrochemical sensor provides high sensitivity, enhanced selectivity, good reproducibility and practical applicability. Keywords: pyritinol, carbon nanofiber, gold nanoparticle, sensor, square-wave voltammetryApetrei IMApetrei CDove Medical Pressarticlepyritinolcarbon nanofibergold nanoparticlesensorsquare-wave voltammetryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5177-5188 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	pyritinol carbon nanofiber gold nanoparticle sensor square-wave voltammetry Medicine (General) R5-920
spellingShingle	pyritinol carbon nanofiber gold nanoparticle sensor square-wave voltammetry Medicine (General) R5-920 Apetrei IM Apetrei C Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
description	Irina Mirela Apetrei,1 Constantin Apetrei2 1Department of Pharmaceutical Sciences, Medical and Pharmaceutical Research Center, Faculty of Medicine and Pharmacy, 2Department of Chemistry, Physics and Environment, Faculty of Sciences and Environment, “Dunarea de Jos” University of Galati, Galati, Romania Abstract: A novel and highly sensitive electrochemical method for the detection of pyritinol in pharmaceutical products and serum samples has been accomplished based on voltamperometric response of pyritinol in carbon nanofiber-gold nanoparticle (CNF-GNP)-modified screen-printed carbon electrode (SPCE). The electrochemical response of pyritinol to CNF-GNP-modified SPCE was studied by cyclic voltammetry and square-wave voltammetry (SWV). Under optimized working conditions, the novel sensor shows excellent voltamperometric response toward pyritinol. The SWV study shows significantly enhanced electrochemical response for pyritinol in CNF-GNP-modified SPCE providing high sensitivity to the novel sensor for pyritinol detection. The peak current for pyritinol is found to be linear with the concentration in the range 1.0×10-8–5.0×10-5 M with a detection limit of 6.23×10-9 M using SWV as the detection method. The viability of the new developed sensor for the analytical purposes was studied by performing experiments on various commercial pharmaceutical products and blood serum samples, which yielded adequate recoveries of pyritinol. The novel electrochemical sensor provides high sensitivity, enhanced selectivity, good reproducibility and practical applicability. Keywords: pyritinol, carbon nanofiber, gold nanoparticle, sensor, square-wave voltammetry
format	article
author	Apetrei IM Apetrei C
author_facet	Apetrei IM Apetrei C
author_sort	Apetrei IM
title	Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
title_short	Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
title_full	Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
title_fullStr	Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
title_full_unstemmed	Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
title_sort	highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/5c9403418ebc4f048f95630f895c4ad1
work_keys_str_mv	AT apetreiim highlysensitivevoltamperometricdeterminationofpyritinolusingcarbonnanofibergoldnanoparticlecompositescreenprintedcarbonelectrode AT apetreic highlysensitivevoltamperometricdeterminationofpyritinolusingcarbonnanofibergoldnanoparticlecompositescreenprintedcarbonelectrode
_version_	1718403556868882432

Highly sensitive voltamperometric determination of pyritinol using carbon nanofiber/gold nanoparticle composite screen-printed carbon electrode

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