Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy

We examined the role of ATP and high mobility group box 1 (HMGB1) in paclitaxel-induced peripheral neuropathy (PIPN). PIPN in mice was prevented by HMGB1 neutralization, macrophage depletion, and P2X7 or P2X4 blockade. Paclitaxel and ATP synergistically released HMGB1 from macrophage-like RAW264.7 c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Risa Domoto, Fumiko Sekiguchi, Riki Kamaguchi, Maiko Iemura, Hiroki Yamanishi, Maho Tsubota, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	High mobility group box 1 (HMGB1) Paclitaxel Chemotherapy-induced peripheral neuropathy (CIPN) ATP Neuroimmune crosstalk Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/5c9863c762b644f49b16ef8614d4b4ff
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:5c9863c762b644f49b16ef8614d4b4ff
record_format	dspace
spelling	oai:doaj.org-article:5c9863c762b644f49b16ef8614d4b4ff2021-11-26T04:24:41ZRole of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy1347-861310.1016/j.jphs.2021.11.003https://doaj.org/article/5c9863c762b644f49b16ef8614d4b4ff2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1347861321001109https://doaj.org/toc/1347-8613We examined the role of ATP and high mobility group box 1 (HMGB1) in paclitaxel-induced peripheral neuropathy (PIPN). PIPN in mice was prevented by HMGB1 neutralization, macrophage depletion, and P2X7 or P2X4 blockade. Paclitaxel and ATP synergistically released HMGB1 from macrophage-like RAW264.7 cells, but not neuron-like NG108-15 cells. The paclitaxel-induced HMGB1 release from RAW264.7 cells was accelerated by co-culture with NG108-15 cells in a manner dependent on P2X7 or P2X4. Paclitaxel released ATP from NG108-15 cells, but not RAW264.7 cells. Thus, PIPN is considered to involve acceleration of HMGB1 release from macrophages through P2X7 and P2X4 activation by neuron-derived ATP.Risa DomotoFumiko SekiguchiRiki KamaguchiMaiko IemuraHiroki YamanishiMaho TsubotaDengli WangMasahiro NishiboriAtsufumi KawabataElsevierarticleHigh mobility group box 1 (HMGB1)PaclitaxelChemotherapy-induced peripheral neuropathy (CIPN)ATPNeuroimmune crosstalkTherapeutics. PharmacologyRM1-950ENJournal of Pharmacological Sciences, Vol 148, Iss 1, Pp 156-161 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	High mobility group box 1 (HMGB1) Paclitaxel Chemotherapy-induced peripheral neuropathy (CIPN) ATP Neuroimmune crosstalk Therapeutics. Pharmacology RM1-950
spellingShingle	High mobility group box 1 (HMGB1) Paclitaxel Chemotherapy-induced peripheral neuropathy (CIPN) ATP Neuroimmune crosstalk Therapeutics. Pharmacology RM1-950 Risa Domoto Fumiko Sekiguchi Riki Kamaguchi Maiko Iemura Hiroki Yamanishi Maho Tsubota Dengli Wang Masahiro Nishibori Atsufumi Kawabata Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
description	We examined the role of ATP and high mobility group box 1 (HMGB1) in paclitaxel-induced peripheral neuropathy (PIPN). PIPN in mice was prevented by HMGB1 neutralization, macrophage depletion, and P2X7 or P2X4 blockade. Paclitaxel and ATP synergistically released HMGB1 from macrophage-like RAW264.7 cells, but not neuron-like NG108-15 cells. The paclitaxel-induced HMGB1 release from RAW264.7 cells was accelerated by co-culture with NG108-15 cells in a manner dependent on P2X7 or P2X4. Paclitaxel released ATP from NG108-15 cells, but not RAW264.7 cells. Thus, PIPN is considered to involve acceleration of HMGB1 release from macrophages through P2X7 and P2X4 activation by neuron-derived ATP.
format	article
author	Risa Domoto Fumiko Sekiguchi Riki Kamaguchi Maiko Iemura Hiroki Yamanishi Maho Tsubota Dengli Wang Masahiro Nishibori Atsufumi Kawabata
author_facet	Risa Domoto Fumiko Sekiguchi Riki Kamaguchi Maiko Iemura Hiroki Yamanishi Maho Tsubota Dengli Wang Masahiro Nishibori Atsufumi Kawabata
author_sort	Risa Domoto
title	Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
title_short	Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
title_full	Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
title_fullStr	Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
title_full_unstemmed	Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy
title_sort	role of neuron-derived atp in paclitaxel-induced hmgb1 release from macrophages and peripheral neuropathy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/5c9863c762b644f49b16ef8614d4b4ff
work_keys_str_mv	AT risadomoto roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT fumikosekiguchi roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT rikikamaguchi roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT maikoiemura roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT hirokiyamanishi roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT mahotsubota roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT dengliwang roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT masahironishibori roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy AT atsufumikawabata roleofneuronderivedatpinpaclitaxelinducedhmgb1releasefrommacrophagesandperipheralneuropathy
_version_	1718409902666285056

Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy

Ejemplares similares