Pharmacologic management of overactive bladder

Sum Lam1,2, Olga Hilas1,31St. John’s University, College of Pharmacy and Allied Health Professions, Department of Clinical Pharmacy Practice, Queens, New York, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, New York, USA; 3Department of Pharmacy, New York-Pres...

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Autores principales:	Sum Lam, Olga Hilas
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2007
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5c98a2c11dfe49b3a67a6dad7fa5080e
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spelling	oai:doaj.org-article:5c98a2c11dfe49b3a67a6dad7fa5080e2021-12-02T08:30:56ZPharmacologic management of overactive bladder1178-1998https://doaj.org/article/5c98a2c11dfe49b3a67a6dad7fa5080e2007-10-01T00:00:00Zhttps://www.dovepress.com/pharmacologic-management-of-overactive-bladder-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Sum Lam1,2, Olga Hilas1,31St. John’s University, College of Pharmacy and Allied Health Professions, Department of Clinical Pharmacy Practice, Queens, New York, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, New York, USA; 3Department of Pharmacy, New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USAAbstract: Overactive bladder (OAB) is a prevalent and costly condition that can affect any age group. Typical symptoms include urinary urgency, frequency, incontinence and nocturia. OAB occurs as a result of abnormal contractions of the bladder detrusor muscle caused by the stimulation of certain muscarinic receptors. Therefore, antimuscarinic agents have long been considered the mainstay of pharmacologic treatment for OAB. Currently, there are five such agents approved for the management of OAB in the United States: oxybutynin, tolterodine, trospium, solifenacin and darifenacin. This article summarizes the efficacy, contraindications, precautions, dosing and common side effects of these agents. All available clinical trials on trospium, solifenacin and darifenacin were reviewed to determine its place in therapy.Keywords: overactive bladder, urinary incontinence, pharmacologic management, antimuscarinic agents, anticholinergicsSum LamOlga HilasDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 2, Pp 337-345 (2007)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Sum Lam Olga Hilas Pharmacologic management of overactive bladder
description	Sum Lam1,2, Olga Hilas1,31St. John’s University, College of Pharmacy and Allied Health Professions, Department of Clinical Pharmacy Practice, Queens, New York, USA; 2Division of Geriatric Medicine, Winthrop University Hospital, Mineola, New York, USA; 3Department of Pharmacy, New York-Presbyterian Hospital, Weill Cornell Medical Center, New York, New York, USAAbstract: Overactive bladder (OAB) is a prevalent and costly condition that can affect any age group. Typical symptoms include urinary urgency, frequency, incontinence and nocturia. OAB occurs as a result of abnormal contractions of the bladder detrusor muscle caused by the stimulation of certain muscarinic receptors. Therefore, antimuscarinic agents have long been considered the mainstay of pharmacologic treatment for OAB. Currently, there are five such agents approved for the management of OAB in the United States: oxybutynin, tolterodine, trospium, solifenacin and darifenacin. This article summarizes the efficacy, contraindications, precautions, dosing and common side effects of these agents. All available clinical trials on trospium, solifenacin and darifenacin were reviewed to determine its place in therapy.Keywords: overactive bladder, urinary incontinence, pharmacologic management, antimuscarinic agents, anticholinergics
format	article
author	Sum Lam Olga Hilas
author_facet	Sum Lam Olga Hilas
author_sort	Sum Lam
title	Pharmacologic management of overactive bladder
title_short	Pharmacologic management of overactive bladder
title_full	Pharmacologic management of overactive bladder
title_fullStr	Pharmacologic management of overactive bladder
title_full_unstemmed	Pharmacologic management of overactive bladder
title_sort	pharmacologic management of overactive bladder
publisher	Dove Medical Press
publishDate	2007
url	https://doaj.org/article/5c98a2c11dfe49b3a67a6dad7fa5080e
work_keys_str_mv	AT sumlam pharmacologicmanagementofoveractivebladder AT olgahilas pharmacologicmanagementofoveractivebladder
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Pharmacologic management of overactive bladder

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