Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis

The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin...

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Autores principales:	Midori Filiz Nishimura, Yoshito Nishimura, Asami Nishikori, Yukina Maekawa, Kanna Maehama, Tadashi Yoshino, Yasuharu Sato
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Castleman disease hyaline vascular type unicentric Castleman disease abdominal cavity mediastinum Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5ca0af9a0c034d4b9c5040aefa514a97
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spelling	oai:doaj.org-article:5ca0af9a0c034d4b9c5040aefa514a972021-11-25T17:20:42ZClinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis10.3390/diagnostics111120082075-4418https://doaj.org/article/5ca0af9a0c034d4b9c5040aefa514a972021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/2008https://doaj.org/toc/2075-4418The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin detected by chest radiography. In recent years, improved access to imaging modalities has provided new insights in the diagnosis of this condition. In this study, we reviewed the detailed clinical and pathological findings of 38 HV-UCD cases (20 males and 18 females, mean age: 42.8 years). The most common site involved was the abdominal cavity (34.2%), followed by mediastinum (23.7%) and retroperitoneum (15.8%). In the abdominal cavity, mesenteric origin was the most common. The mean size of masses was 4.8 cm. Pathologically, thick hyalinized collagen fibers surrounding large blood vessels and calcification were observed (81.6% and 23.7%, respectively). Multinucleated giant cells resembling Warthin–Finkeldey cell were also observed in occasional cases (23.7%). This is a unique paper that summarizes detailed clinical and pathological findings of a large series of a rare disease. The clinical information presented in this paper is more plausible than previous views and is useful for accurate diagnosis and understanding of the disease.Midori Filiz NishimuraYoshito NishimuraAsami NishikoriYukina MaekawaKanna MaehamaTadashi YoshinoYasuharu SatoMDPI AGarticleCastleman diseasehyaline vascular typeunicentric Castleman diseaseabdominal cavitymediastinumMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 2008, p 2008 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Castleman disease hyaline vascular type unicentric Castleman disease abdominal cavity mediastinum Medicine (General) R5-920
spellingShingle	Castleman disease hyaline vascular type unicentric Castleman disease abdominal cavity mediastinum Medicine (General) R5-920 Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Yukina Maekawa Kanna Maehama Tadashi Yoshino Yasuharu Sato Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
description	The first case of hyaline vascular type of unicentric Castleman disease (HV-UCD) was reported more than six decades ago. Since patients with HV-UCD are often asymptomatic and this condition is generally discovered incidentally on imaging tests, most of the previous reports were of mediastinal origin detected by chest radiography. In recent years, improved access to imaging modalities has provided new insights in the diagnosis of this condition. In this study, we reviewed the detailed clinical and pathological findings of 38 HV-UCD cases (20 males and 18 females, mean age: 42.8 years). The most common site involved was the abdominal cavity (34.2%), followed by mediastinum (23.7%) and retroperitoneum (15.8%). In the abdominal cavity, mesenteric origin was the most common. The mean size of masses was 4.8 cm. Pathologically, thick hyalinized collagen fibers surrounding large blood vessels and calcification were observed (81.6% and 23.7%, respectively). Multinucleated giant cells resembling Warthin–Finkeldey cell were also observed in occasional cases (23.7%). This is a unique paper that summarizes detailed clinical and pathological findings of a large series of a rare disease. The clinical information presented in this paper is more plausible than previous views and is useful for accurate diagnosis and understanding of the disease.
format	article
author	Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Yukina Maekawa Kanna Maehama Tadashi Yoshino Yasuharu Sato
author_facet	Midori Filiz Nishimura Yoshito Nishimura Asami Nishikori Yukina Maekawa Kanna Maehama Tadashi Yoshino Yasuharu Sato
author_sort	Midori Filiz Nishimura
title	Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_short	Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_full	Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_fullStr	Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_full_unstemmed	Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis
title_sort	clinical and pathological characteristics of hyaline-vascular type unicentric castleman disease: a 20-year retrospective analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5ca0af9a0c034d4b9c5040aefa514a97
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Clinical and Pathological Characteristics of Hyaline-Vascular Type Unicentric Castleman Disease: A 20-Year Retrospective Analysis

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