A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine...

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Autores principales:	Guoliang Zhang, Nicole A. deWeerd, Sebastian A. Stifter, Lei Liu, Boping Zhou, Wenfei Wang, Yiping Zhou, Binwu Ying, Xuejiao Hu, Antony Y. Matthews, Magda Ellis, James A. Triccas, Paul J. Hertzog, Warwick J. Britton, Xinchun Chen, Carl G. Feng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5ca2351b99a54111a84374d6e929ba77
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spelling	oai:doaj.org-article:5ca2351b99a54111a84374d6e929ba772021-12-02T17:31:30ZA proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans10.1038/s41467-017-02611-z2041-1723https://doaj.org/article/5ca2351b99a54111a84374d6e929ba772018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02611-zhttps://doaj.org/toc/2041-1723The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine response.Guoliang ZhangNicole A. deWeerdSebastian A. StifterLei LiuBoping ZhouWenfei WangYiping ZhouBinwu YingXuejiao HuAntony Y. MatthewsMagda EllisJames A. TriccasPaul J. HertzogWarwick J. BrittonXinchun ChenCarl G. FengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
description	The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine response.
format	article
author	Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng
author_facet	Guoliang Zhang Nicole A. deWeerd Sebastian A. Stifter Lei Liu Boping Zhou Wenfei Wang Yiping Zhou Binwu Ying Xuejiao Hu Antony Y. Matthews Magda Ellis James A. Triccas Paul J. Hertzog Warwick J. Britton Xinchun Chen Carl G. Feng
author_sort	Guoliang Zhang
title	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
title_short	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
title_full	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
title_fullStr	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
title_full_unstemmed	A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans
title_sort	proline deletion in ifnar1 impairs ifn-signaling and underlies increased resistance to tuberculosis in humans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/5ca2351b99a54111a84374d6e929ba77
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A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

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