A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

The role of type I interferons in bacterial infection is less clear than it is in viral infection. Here, the authors show that genetic variation of the human IFNAR1 gene is associated with decreased susceptibility to tuberculosis and identify a role for the IFNAR1 inter-domain region in the cytokine...

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Main Authors: Guoliang Zhang, Nicole A. deWeerd, Sebastian A. Stifter, Lei Liu, Boping Zhou, Wenfei Wang, Yiping Zhou, Binwu Ying, Xuejiao Hu, Antony Y. Matthews, Magda Ellis, James A. Triccas, Paul J. Hertzog, Warwick J. Britton, Xinchun Chen, Carl G. Feng
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/5ca2351b99a54111a84374d6e929ba77
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https://doaj.org/article/5ca2351b99a54111a84374d6e929ba77

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