Neuroimaging biomarkers to associate obesity and negative emotions

Abstract Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explor...

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Autores principales:	Bo-yong Park, Jisu Hong, Hyunjin Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5ca4f2ba904b41a1a1563e611ba36c07
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spelling	oai:doaj.org-article:5ca4f2ba904b41a1a1563e611ba36c072021-12-02T11:52:43ZNeuroimaging biomarkers to associate obesity and negative emotions10.1038/s41598-017-08272-82045-2322https://doaj.org/article/5ca4f2ba904b41a1a1563e611ba36c072017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08272-8https://doaj.org/toc/2045-2322Abstract Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explored. We obtained 196 emotion task functional magnetic resonance imaging (t-fMRI) from the Human Connectome Project database using a sampling scheme similar to a bootstrapping approach. Brain regions were specified by automated anatomical labeling atlas and the brain activity (z-statistics) of each brain region was correlated with body mass index (BMI) values. Regions with significant correlation were identified and the brain activity of the identified regions was correlated with emotion-related clinical scores. Hippocampus, amygdala, and inferior temporal gyrus consistently showed significant correlation between brain activity and BMI and only the brain activity in amygdala consistently showed significant negative correlation with fear-affect score. The brain activity in amygdala derived from t-fMRI might be good neuroimaging biomarker for explaining the relationship between obesity and a negative emotional state.Bo-yong ParkJisu HongHyunjin ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bo-yong Park Jisu Hong Hyunjin Park Neuroimaging biomarkers to associate obesity and negative emotions
description	Abstract Obesity is a serious medical condition highly associated with health problems such as diabetes, hypertension, and stroke. Obesity is highly associated with negative emotional states, but the relationship between obesity and emotional states in terms of neuroimaging has not been fully explored. We obtained 196 emotion task functional magnetic resonance imaging (t-fMRI) from the Human Connectome Project database using a sampling scheme similar to a bootstrapping approach. Brain regions were specified by automated anatomical labeling atlas and the brain activity (z-statistics) of each brain region was correlated with body mass index (BMI) values. Regions with significant correlation were identified and the brain activity of the identified regions was correlated with emotion-related clinical scores. Hippocampus, amygdala, and inferior temporal gyrus consistently showed significant correlation between brain activity and BMI and only the brain activity in amygdala consistently showed significant negative correlation with fear-affect score. The brain activity in amygdala derived from t-fMRI might be good neuroimaging biomarker for explaining the relationship between obesity and a negative emotional state.
format	article
author	Bo-yong Park Jisu Hong Hyunjin Park
author_facet	Bo-yong Park Jisu Hong Hyunjin Park
author_sort	Bo-yong Park
title	Neuroimaging biomarkers to associate obesity and negative emotions
title_short	Neuroimaging biomarkers to associate obesity and negative emotions
title_full	Neuroimaging biomarkers to associate obesity and negative emotions
title_fullStr	Neuroimaging biomarkers to associate obesity and negative emotions
title_full_unstemmed	Neuroimaging biomarkers to associate obesity and negative emotions
title_sort	neuroimaging biomarkers to associate obesity and negative emotions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5ca4f2ba904b41a1a1563e611ba36c07
work_keys_str_mv	AT boyongpark neuroimagingbiomarkerstoassociateobesityandnegativeemotions AT jisuhong neuroimagingbiomarkerstoassociateobesityandnegativeemotions AT hyunjinpark neuroimagingbiomarkerstoassociateobesityandnegativeemotions
_version_	1718394925396000768

Neuroimaging biomarkers to associate obesity and negative emotions

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