Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine

Action-outcome learning requires the prelimbic prefrontal cortex. Here the authors report that fasudil, a Rho kinase inhibitor, reduces dendritic spine densities on prelimbic neurons in an activity-dependent manner, stimulating goal-directed actions, and reducing habitual responding for cocaine.

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Autores principales:	Andrew M. Swanson, Lauren M. DePoy, Shannon L. Gourley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5cac10ccf6b744d28809548ef004bc96
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spelling	oai:doaj.org-article:5cac10ccf6b744d28809548ef004bc962021-12-02T14:42:07ZInhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine10.1038/s41467-017-01915-42041-1723https://doaj.org/article/5cac10ccf6b744d28809548ef004bc962017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01915-4https://doaj.org/toc/2041-1723Action-outcome learning requires the prelimbic prefrontal cortex. Here the authors report that fasudil, a Rho kinase inhibitor, reduces dendritic spine densities on prelimbic neurons in an activity-dependent manner, stimulating goal-directed actions, and reducing habitual responding for cocaine.Andrew M. SwansonLauren M. DePoyShannon L. GourleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew M. Swanson Lauren M. DePoy Shannon L. Gourley Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
description	Action-outcome learning requires the prelimbic prefrontal cortex. Here the authors report that fasudil, a Rho kinase inhibitor, reduces dendritic spine densities on prelimbic neurons in an activity-dependent manner, stimulating goal-directed actions, and reducing habitual responding for cocaine.
format	article
author	Andrew M. Swanson Lauren M. DePoy Shannon L. Gourley
author_facet	Andrew M. Swanson Lauren M. DePoy Shannon L. Gourley
author_sort	Andrew M. Swanson
title	Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
title_short	Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
title_full	Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
title_fullStr	Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
title_full_unstemmed	Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
title_sort	inhibiting rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/5cac10ccf6b744d28809548ef004bc96
work_keys_str_mv	AT andrewmswanson inhibitingrhokinasepromotesgoaldirecteddecisionmakingandblockshabitualrespondingforcocaine AT laurenmdepoy inhibitingrhokinasepromotesgoaldirecteddecisionmakingandblockshabitualrespondingforcocaine AT shannonlgourley inhibitingrhokinasepromotesgoaldirecteddecisionmakingandblockshabitualrespondingforcocaine
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Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine

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