Inhibiting Rho kinase promotes goal-directed decision making and blocks habitual responding for cocaine

Action-outcome learning requires the prelimbic prefrontal cortex. Here the authors report that fasudil, a Rho kinase inhibitor, reduces dendritic spine densities on prelimbic neurons in an activity-dependent manner, stimulating goal-directed actions, and reducing habitual responding for cocaine.

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Detalles Bibliográficos
Autores principales: Andrew M. Swanson, Lauren M. DePoy, Shannon L. Gourley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/5cac10ccf6b744d28809548ef004bc96
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